Alejandro A. Schäffer

National Cancer Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

79h-index30.1kcitations710works3.52yr avg
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Research Topics

Cancer Genomics and Diagnostics(107), Cancer Immunotherapy and Biomarkers(66), Single-cell and spatial transcriptomics(66), Immunodeficiency and Autoimmune Disorders(53), CAR-T cell therapy research(48)

Publications710 total

Success rates of American clinical oncology trials by geographic factors
Scientific Reports·2026Open Access
Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity
Science Immunology·2025
1111 Single-cell-driven design of logic-gated CAR circuits for enhanced solid tumor immunotherapy
Regular and Young Investigator Award Abstracts·2025Open Access
A machine learning framework for supervised treatment response prediction from tumor transcriptomics: A large-scale pan-cancer study
2025Open Access
Abstract C042: Systematic discovery of logic-gated cell surface targets for enhanced solid tumor CAR therapy through single-cell transcriptomics
Molecular Cancer Therapeutics·2025
Re-evaluation of the contribution of <i>TNFRSF13B</i> variants to antibody deficiency
Journal of Human Immunity·2025· 1 citedOpen Access
Fair molecular feature selection unveils universally tumor lineage-informative methylation sites in colorectal cancer
Bioinformatics·2025Open Access
Abstract 2494: Elucidating developmental methylation programs and cell type compositions in glioblastoma using combinatorial optimization
Cancer Research·2025
Abstract 3752: Single-cell-guided identification of logic-gated combinatorial antigens for effective and safe CAR therapy design
Cancer Research·2025
A systematic evaluation of the therapeutic potential of endogenous-ADAR editors in cancer prevention and treatment
NAR Cancer·2025Open Access
Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy
2025· 6 citedOpen Access
Abstract A033: Identifying logic-gated combinatorial antigens from single-cell transcriptomics data of patient tumors for effective and safe CAR therapy design
Cancer Research·2025
Hallmarks of artificial intelligence contributions to precision oncology
Nature Cancer·2025· 27 citedOpen Access
Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function
Algorithms·2025· 1 citedOpen Access
Supplementary Figure 3 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
2025Open Access
Supplementary Table 3 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
2025Open Access
Supplementary Figure 12 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
2025Open Access
Supplementary Table 4 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
2025Open Access
Supplementary Figure 10 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
2025Open Access
Supplementary Figure 14 from Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
2025Open Access
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Frequent Co-authors

Bodo Grimbacher(19), E. Michael Gertz(12), Richa Agarwala(11), Dietmar Pfeifer(8), Ulrich Salzer(7), Christoph Klein(7), Nima Rezaei(6), Jana Diestelhorst(5), Joie Davis(5), Kaan Boztuǧ(4), Cristina Woellner(4), Ulrich Baumann(4), Aleksandr Morgulis(4), Alexandra F. Freeman(4), Stephen F. Altschul(4), Alla Bulashevska(4), Klaus Warnatz(4), Lennart Hammarström(4), Amos Etzioni(4), Giridharan Appaswamy(4)