Christoph Klein

Roche (Switzerland) — Switzerland

Immunology and Microbiology · Life Sciences

88h-index33.6kcitations483works10.92yr avg
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Research Topics

Immunodeficiency and Autoimmune Disorders(164), Blood disorders and treatments(96), Cardiac Imaging and Diagnostics(58), Immune Cell Function and Interaction(56), Advanced MRI Techniques and Applications(53)

Publications479 total

Organoid platinum-resistance model identifies KRT17 as a biomarker of targeted therapy in ovarian cancer
iScience·2025Open Access
A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases·2025Open Access
HIGH PREVALENCE OF GERMLINE PREDISPOSITION IN PAEDIATRIC MYELODYSPLASTIC SYNDROME: A SINGLE-CENTRE RETROSPECTIVE ANALYSIS
EJC Paediatric Oncology·2025Open Access
Human iPSC-derived bone marrow organoids for AML engraftment and immunotherapy testing
Blood·2025Open Access
Increased dosing of blinatumomab in children and adolescents with Relapsed/Refractory B-lineage acute lymphoblastic leukemia – beneficial safety profile with 30µg/m²/day in a single center study
Blood·2025Open Access
Concomitant Transapical Double Valve Replacement for Severe Native Mitral Regurgitation and Aortic Transcatheter Valve Degeneration
JACC Case Reports·2025Open Access
Surgical and transcatheter aortic valve replacement after orthotopic heart transplantation: a case series
Communications Medicine·2025Open Access
Mutations in <i>VPS18</i> lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis
2025Open Access
Using large language models to extract information from pediatric clinical reports
PLOS Digital Health·2025· 1 citedOpen Access
A collection of patient-derived intestinal organoid lines reveals epithelial pheno-types associated with genetic drivers of pediatric inflammatory bowel disease
2025· 1 citedOpen Access
Distinct heterozygous <i>TTC7A</i> missense variants lead to different intestinal epithelial phenotypes in pediatric IBD
2025Open Access
Transcatheter management of left-sided valvular heart disease following heart transplantation
European Journal of Cardio-Thoracic Surgery·2025· 1 cited
Ontology-guided clustering enables proteomic analysis of rare pediatric disorders
EMBO Molecular Medicine·2025· 1 citedOpen Access
Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders
Research and Practice in Thrombosis and Haemostasis·2025· 1 citedOpen Access
Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy
Nature Medicine·2025· 19 citedOpen Access
The 2024 update of IUIS phenotypic classification of human inborn errors of immunity
Journal of Human Immunity·2025· 76 citedOpen Access
Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee
Journal of Human Immunity·2025· 157 citedOpen Access
A molecular atlas of human granulopoiesis
2025Open Access
P-07.01 Modular targeting of acute myeloid leukemia with anti-P329G adapter CAR T cells
Poster presentations·2025Open Access
Congenital Cardiac Defects in G6PC3 Deficiency: Report of a Mutation and a Literature Review
Immunology and Genetics Journal·2025
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Frequent Co-authors

Capucine Pïcard(14), Steven M. Holland(13), Waleed Al–Herz(12), Jennifer M. Puck(12), Aziz Bousfiha(11), Jean‐Laurent Casanova(11), Bodo Grimbacher(10), Stuart G. Tangye(10), Charlotte Cunningham‐Rundles(10), José Luis Franco(10), Kathleen E. Sullivan(10), Daniel Kotlarz(9), Scott B. Snapper(9), Aleixo M. Muise(9), Talal A. Chatila(8), Amos Etzioni(8), Tomohiro Morio(8), Hans D. Ochs(8), Troy R. Torgerson(8), Kaan Boztuǧ(6)