Jean‐Laurent Casanova

Hôpital Necker-Enfants Malades — France

Immunology and Microbiology · Life Sciences

170h-index118.7kcitations1.4kworks7.72yr avg
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Research Topics

Immunodeficiency and Autoimmune Disorders(594), Immune Cell Function and Interaction(235), Mycobacterium research and diagnosis(187), Tuberculosis Research and Epidemiology(145), Immune Response and Inflammation(137)

Publications1.4k total

Expanding the utility of variant effect predictions with phenotype-specific models
Nature Communications·2025· 1 citedOpen Access
Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR prospective, multicenter cohort study
Intensive Care Medicine Experimental·2025Open Access
Human inborn errors of the alternative NF-κB pathway
Journal of Human Immunity·2025Open Access
Genotypes truncating the intracellular tail of human pre-TCRα: From amorphic to isomorphic
Journal of Human Immunity·2025Open Access
Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza
The Journal of Experimental Medicine·2025· 1 citedOpen Access
Recurrent severe viral infection in a child with inherited complete TBK1 deficiency
Journal of Human Immunity·2025· 1 citedOpen Access
OAS1 and OAS3 genetic variants enhance inflammatory responses to SARS-CoV-2
iScience·2025Open Access
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease
Journal of Human Immunity·2025Open Access
Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India
Journal of Human Immunity·2025Open Access
Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease 2038
The Journal of Immunology·2025Open Access
Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis
The Journal of Experimental Medicine·2025· 1 citedOpen Access
Type I IFNs Decrease SARS-CoV-2 Replication in Human Cardiomyocytes and Increase Cytokine Production in Macrophages
Journal of Clinical Immunology·2025· 1 citedOpen Access
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
UNC Libraries·2025Open Access
A <i>WAS</i> promoter variant underlying Wiskott-Aldrich syndrome in two kindreds
Journal of Human Immunity·2025Open Access
A novel heterozygous pathogenic <i>AIRE</i> variant causing autoimmunity but not infectious susceptibility
Journal of Human Immunity·2025Open Access
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases
Journal of Human Immunity·2025· 1 citedOpen Access
Abundant Yet Aberrant T Helper Cell Responses to <i>Candida albicans</i> Underlie Mucosal Candidiasis in Humans and Mice
European Journal of Immunology·2025Open Access
Novel genotypes, phenotypes, and triggers in humans with OTULIN haploinsufficiency
Journal of Human Immunity·2025Open Access
Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitis
Journal of Human Immunity·2025· 2 citedOpen Access
The seven enigmas of SARS-CoV-2: From the past to the future
Journal of Human Immunity·2025· 1 citedOpen Access
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Frequent Co-authors

Capucine Pïcard(25), Anne Puel(17), Laurent Abel(17), Steven M. Holland(14), Alain Fischer(13), Stéphanie Boisson‐Dupuis(12), Jacinta Bustamante(12), Emmanuelle Jouanguy(10), Amos Etzioni(10), Hans D. Ochs(9), Luigi D. Notarangelo(8), Maya Chrabieh(8), Charlotte Cunningham‐Rundles(8), Jennifer M. Puck(8), Dinakantha Kumararatne(8), Aziz Bousfiha(7), Christoph Klein(7), Saleh Al‐Muhsen(7), Rainer Döffinger(7), Stuart G. Tangye(6)