Cheol K. Chung

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.3kcitations56works1.82yr avg
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Research Topics

Chemical Synthesis and Analysis(13), Synthetic Organic Chemistry Methods(13), Catalytic C–H Functionalization Methods(12), Asymmetric Synthesis and Catalysis(7), Catalytic Cross-Coupling Reactions(7)

Publications56 total

Selective Synthesis of <i>N</i><sup>6</sup>,3′,5′-Tripivaloyladenosine via Dynamic Kinetic Crystallization and Regioselective Preparation of Pivalated 2′-Deoxy-2′-fluoroarabinoadenosines
Organic Process Research & Development·2024
The First GMP Synthesis of MK-2118, a Small Molecule Agonist for Stimulator of Interferon Genes
Organic Process Research & Development·2024· 8 cited
Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
Organic Process Research & Development·2024· 1 cited
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Organic Process Research & Development·2024· 1 cited
Development of a Thiophosphorylation Process for the Synthesis of 2′F-Thio-Adenosine Monophosphate
Organic Process Research & Development·2024· 1 cited
CCDC 2224106: Experimental Crystal Structure Determination
The Cambridge Structural Database·2024Open Access
Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib
Organic Process Research & Development·2023· 13 cited
Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)
Organic Process Research & Development·2023· 3 cited
Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction
Organic Process Research & Development·2023· 6 cited
Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib
Organic Process Research & Development·2023· 8 cited
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides
Organic Process Research & Development·2023· 4 cited
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part I: Accessing a Keto-Nucleoside Intermediate from Guanosine
Organic Process Research & Development·2023· 2 cited
CCDC 2215968: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
CCDC 2215969: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene
Green Chemistry·2022· 29 cited
Utilizing Biocatalysis and an Unprecedented Sulfolane-mediated Reductive Acetal Opening to Access Nemtabrutinib from Cyrene
2022Open Access
A Unified Strategy to Fluorinated Nucleoside Analogues <i>Via</i> an Electrophilic Manifold
Organic Letters·2022· 6 cited
A Diastereoselective Method for the Construction of <i>syn</i>-2′-Deoxy-2′-fluoronucleosides
Organic Letters·2022· 14 cited
Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454
Journal of the American Chemical Society·2022· 45 cited
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation
Organic Process Research & Development·2021· 8 cited
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Frequent Co-authors

Nadine Kuhl(9), Barry M. Trost(8), David A. Thaisrivongs(7), Ben W. H. Turnbull(6), Erik D. Guetschow(6), Nelo R. Rivera(5), Peter E. Maligres(5), Yining Ji(5), Richard Desmond(5), James Corry(5), Guy R. Humphrey(4), Tamas Benkovics(4), Zachary E. X. Dance(4), Zhijian Liu(4), Andrew J. Neel(4), Mikhail Reibarkh(4), Zhiguo J. Song(4), Lushi Tan(4), Andrew P. J. Brunskill(4), Reed T. Larson(4)