Lijs Beke

Université Pelefero Gon Coulibaly — CI

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index546citations27works0.02yr avg
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Research Topics

Cancer-related gene regulation(11), FOXO transcription factor regulation(8), Epigenetics and DNA Methylation(6), RNA modifications and cancer(4), MicroRNA in disease regulation(2)

Publications27 total

Quantitative Structure Activity Relationship (QSAR) Anticancer Modeling of the MCF-7 Cell Line of Phthalocyanine Derivatives
International Research Journal of Pure and Applied Chemistry·2025
QSAR Modeling of phthalocyanine Derivatives as Potential Anticancer Agents against Hepatocellular Carcinoma
World Journal of Advanced Research and Reviews·2025Open Access
Abstract C113: Discovery of Best-in-Class FGFR3 small molecule inhibitors with high isoform selectivity and activity against gatekeeper mutations
Molecular Cancer Therapeutics·2025
Abstract C011: Discovery of novel SMARCA2 small molecule inhibitors with best-in-class potency and selectivity for the treatment of SMARCA4-mutant cancers
Molecular Cancer Therapeutics·2025
Abstract C012: Discovery of a Best-in-Class small molecule p53 Y220C reactivator: Breaking through the potency ceiling
Molecular Cancer Therapeutics·2025
Supplementary Methods from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
Data from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
Supplementary Tables from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
Supplementary Figures from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode
ACS Medicinal Chemistry Letters·2020· 22 citedOpen Access
Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
Bioscience Reports·2018· 2 citedOpen Access
Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent <i>in vitro</i> and <i>in vivo</i> activity, demonstrated in several lung cancer models
Cancer Research·2018· 25 cited
Withdrawal: Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.
Journal of Biological Chemistry·2017· 6 citedOpen Access
Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models
Cancer Research·2017· 20 cited
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
Bioscience Reports·2015· 72 citedOpen Access
Abstract 2936: JNJ-47117096, a selective small molecule inhibitor of the MELK oncogene decreases DNA damage tolerance in highly proliferating cancer cells
Cancer Research·2014· 1 cited
Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
ACS Medicinal Chemistry Letters·2014· 31 citedOpen Access
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
ACS Medicinal Chemistry Letters·2014· 29 citedOpen Access
Structure of MELK in complex with inhibitors
2014
Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells
Journal of Biological Chemistry·2013· 43 citedOpen Access
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Frequent Co-authors

Dirk Brehmer(15), Mathieu Bollen(12), Lieven Meerpoel(12), Monique Beullens(10), Aleyde Van Eynde(9), An Boeckx(8), Erika van Heerde(8), Tongfei Wu(8), Joannes T. M. Linders(7), Petra Vinken(7), Weimei Sun(7), Vineet Pande(7), Hillary J. Millar(6), Geert Mannens(6), Christopher Moy(6), Sylvie Laquerre(6), Matthew V. Lorenzi(6), Thomas Nys(6), Marcel Viellevoye(6), Cenk Kığ(5)