R. Dustan Sarazan

Medicine · Health Sciences

17h-index979citations49works0.02yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(22), Ion channel regulation and function(7), Cardiovascular Function and Risk Factors(7), Veterinary Pharmacology and Anesthesia(6), Antibiotics Pharmacokinetics and Efficacy(5)

Publications49 total

Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation
Journal of Pharmacological and Toxicological Methods·2018· 1 cited
The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs
Journal of Pharmacological and Toxicological Methods·2018· 3 citedOpen Access
An Assessment of Drug-Induced Changes in Cardiac Inotropy and Lusitropy Parameters in Dogs: Results from a HESI-sponsored Consortium
Journal of Pharmacological and Toxicological Methods·2017
Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance
ILAR Journal·2016· 9 citedOpen Access
A HESI consortium update on cardiac contractility endpoints
Journal of Pharmacological and Toxicological Methods·2016· 1 cited
Comparison of direct and ultrasound-derived pulse wave velocity measurement in conscious and anesthetized Wistar rats
Journal of Pharmacological and Toxicological Methods·2015
The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium
Journal of Pharmacological and Toxicological Methods·2015· 54 citedOpen Access
Improved Signal Quality and Sensitivity Using Intravascular Placement of Solid Tip ECG Leads in Rats
The FASEB Journal·2015
Demonstration of simultaneous automated blood sample collection and recording of radiotelemetered physiologic measurements in caged unrestrained cynomolgus macaques
Journal of Pharmacological and Toxicological Methods·2014
Health and environmental sciences institute integrated strategies working group: Update on the evaluation of drug-induced changes in the cardiac inotropy in dogs
Journal of Pharmacological and Toxicological Methods·2014· 1 cited
Opportunities to meet clinical cardio-oncology needs with new approaches to non-clinical safety assessment
Progress in Pediatric Cardiology·2014· 1 citedOpen Access
Cardiovascular pressure measurement in safety assessment studies: Technology requirements and potential errors
Journal of Pharmacological and Toxicological Methods·2014· 18 cited
Improved signal quality using solid tip vascular placement of ECG leads in rats (LB667)
The FASEB Journal·2014
The QT interval of the electrocardiogram
Elsevier eBooks·2014· 1 cited
The QT Interval of the Electrocardiogram
Elsevier eBooks·2014· 5 cited
HESI Cardic Safety Committee: Prospective studies to evaluate the sensitivity of animal models to predict effects of human drugs on cardiac contractility
Journal of Pharmacological and Toxicological Methods·2013
A public–private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee
Journal of Pharmacological and Toxicological Methods·2013· 27 citedOpen Access
A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animals
Journal of Pharmacological and Toxicological Methods·2012
Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studies
Journal of Pharmacological and Toxicological Methods·2012· 35 cited
Comparison of ECG signals and arrhythmia detection using jacketed external telemetry and implanted telemetry in monkeys
Journal of Pharmacological and Toxicological Methods·2011· 8 cited
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Frequent Co-authors

Brian D. Guth(8), Jennifer Doyle(7), John Koerner(6), Jennifer Pierson(6), Eric I. Rossman(6), Scott W. Mittelstadt(5), Syril Pettit(5), Alan Y. Chiang(5), Michael K. Pugsley(5), Harold E. Garner(5), Angela Jenkins(5), Bradley W. Main(5), Brian R. Berridge(5), Thomas W. Beck(5), Andrea Z. Mitchell(4), Michael J. Engwall(4), Peter Hoffmann(4), Jacqueline A. Walisser(4), C. Michael Foley(4), D. M. Griggs(4)