John Koerner

Medicine · Health Sciences

19h-index1.4kcitations45works14.02yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(33), Ion channel regulation and function(10), Cardiac Ischemia and Reperfusion(6), Cardiac Imaging and Diagnostics(5), Animal testing and alternatives(4)

Publications45 total

An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety
Clinical and Translational Science·2024· 14 citedOpen Access
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans
Toxicological Sciences·2022· 42 citedOpen Access
Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates)
Clinical Pharmacology & Therapeutics·2020· 92 citedOpen Access
Cardiovascular data acquisition and analysis: An SPS industry survey
Journal of Pharmacological and Toxicological Methods·2020
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation
International Journal of Toxicology·2020· 10 cited
Prediction of drug-effects on cardiac repolarization in humans: What can we learn from the past to refine our drug discovery strategies?
Journal of Pharmacological and Toxicological Methods·2019
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes
Frontiers in Pharmacology·2019· 54 citedOpen Access
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms
Frontiers in Pharmacology·2019· 28 citedOpen Access
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium
International Journal of Toxicology·2018· 15 citedOpen Access
Corrigendum to An overview of the safety pharmacology society strategic plan [Journal of Pharmacological and Toxicological Methods 93 (2018) 35–45]
Journal of Pharmacological and Toxicological Methods·2018
The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs
Journal of Pharmacological and Toxicological Methods·2018· 3 citedOpen Access
An overview of the safety pharmacology society strategic plan
Journal of Pharmacological and Toxicological Methods·2018· 8 cited
Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium
British Journal of Pharmacology·2017· 65 citedOpen Access
A SPS Survey on Cardiovascular Safety Pharmacology Practices Assessing Proarrhythmia Risk in Drug Safety Testing: State of the Art Prior to Implementation of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) Paradigm
Journal of Pharmacological and Toxicological Methods·2017
An Assessment of Drug-Induced Changes in Cardiac Inotropy and Lusitropy Parameters in Dogs: Results from a HESI-sponsored Consortium
Journal of Pharmacological and Toxicological Methods·2017
An Overview of the Safety Pharmacology Society (SPS) Strategic Plan (2016-2018)
Journal of Pharmacological and Toxicological Methods·2017· 3 cited
Can Nonclinical Repolarization Assays Predict the Results of Clinical Thorough QT Studies? A HESI-FDA Retrospective Analysis
Journal of Pharmacological and Toxicological Methods·2017
Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative
Journal of Pharmacological and Toxicological Methods·2017· 68 citedOpen Access
Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice
Journal of Pharmacological and Toxicological Methods·2017· 34 citedOpen Access
An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs
Journal of Pharmacological and Toxicological Methods·2017· 16 citedOpen Access
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Frequent Co-authors

Michael K. Pugsley(20), Jean‐Pierre Valentin(17), Jennifer Pierson(13), Hugo M. Vargas(12), Simon Authier(11), Syril Pettit(10), Todd Wisialowski(10), Krystle Correll(9), Gary A. Gintant(9), Brian D. Guth(9), Michael J. Engwall(9), Matthew Skinner(7), R. Dustan Sarazan(6), James Willard(6), Jean‐Michel Guillon(6), Scott W. Mittelstadt(5), Stanley T. Parish(5), Alan Y. Chiang(5), Jennifer Doyle(5), Peter Hoffmann(5)