Alfred W. Legasse

Oregon National Primate Research Center — United States

Immunology and Microbiology · Life Sciences

34h-index6.9kcitations62works0.02yr avg
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Research Topics

HIV Research and Treatment(24), Immune Cell Function and Interaction(22), Cytomegalovirus and herpesvirus research(21), T-cell and B-cell Immunology(18), Herpesvirus Infections and Treatments(13)

Publications62 total

Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques
Immunity·2023· 22 citedOpen Access
A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques
UNC Libraries·2021Open Access
A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques
UNC Libraries·2020Open Access
Terumo spectra optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection
Journal of Clinical Apheresis·2020· 4 citedOpen Access
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
UNC Libraries·2020Open Access
Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications
Xenotransplantation·2020· 11 citedOpen Access
Donor T cell chimerism correlates with viral reservoir clearance following allogeneic stem cell transplantation in fully cART-suppressed Mauritian cynomolgus macaques
Journal of Virus Eradication·2019Open Access
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge
Science Translational Medicine·2019· 110 cited
Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity
Science Translational Medicine·2019· 34 cited
Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8<sup>+</sup>T Cells in Nonhuman Primates
Journal of Virology·2019· 5 citedOpen Access
Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound
Nature Medicine·2018· 121 citedOpen Access
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine
Nature Medicine·2018· 263 citedOpen Access
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
Nature Communications·2018· 206 citedOpen Access
The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles
Blood Advances·2018· 89 citedOpen Access
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
Nature Communications·2017· 78 citedOpen Access
The human IL-15 superagonist complex ALT-803 drives SIV-specific CD8+ T cells into B cell follicles
Journal of Virus Eradication·2017· 1 citedOpen Access
Fully MHC-matched allogeneic hematopoietic stem cell transplantation in SIV-infected, cART-suppressed Mauritian cynomolgus macaques indicates GVHD as a reservoir clearance mechanism
Journal of Virus Eradication·2017Open Access
The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques
The Journal of Immunology·2017· 56 citedOpen Access
Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
Nature Communications·2017· 29 citedOpen Access
Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge
Journal of Virology·2017· 24 citedOpen Access
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Frequent Co-authors

Michael K. Axthelm(43), Louis J. Picker(27), Scott G. Hansen(18), Jonah B. Sacha(18), Jeffrey D. Lifson(15), Shannon Planer(15), Jason S. Reed(15), Benjamin J. Burwitz(13), Abigail B. Ventura(12), Michael Piatak(12), Klaus Früh(12), Byung Park(12), Colette M. Hughes(11), Jay A. Nelson(11), Julia C. Ford(10), Tonya Swanson(10), Roxanne M. Gilbride(9), Paul T. Edlefsen(9), Afam A. Okoye(9), Daniel Malouli(9)