Colette M. Hughes

Oregon National Primate Research Center — United States

Medicine · Health Sciences

20h-index3.4kcitations33works3.62yr avg
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Research Topics

Cytomegalovirus and herpesvirus research(26), Immune Cell Function and Interaction(16), HIV Research and Treatment(15), Herpesvirus Infections and Treatments(10), T-cell and B-cell Immunology(7)

Publications33 total

Initial sites of SIV rebound after antiretroviral treatment cessation in rhesus macaques
Nature Microbiology·2026Open Access
Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV
The Journal of Immunology·2025· 1 citedOpen Access
Human cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8 <sup>+</sup> T cells
Science Immunology·2024· 8 citedOpen Access
Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques
Frontiers in Immunology·2024Open Access
Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge
Nature Communications·2024· 9 citedOpen Access
Late gene expression–deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV
JCI Insight·2023· 11 citedOpen Access
Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
Cell Host & Microbe·2022· 23 citedOpen Access
Myeloid cell tropism enables MHC-E–restricted CD8 <sup>+</sup> T cell priming and vaccine efficacy by the RhCMV/SIV vaccine
Science Immunology·2022· 38 citedOpen Access
T cell programming by the cytomegalovirus MHC class I homologue UL18
The Journal of Immunology·2022
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab
Frontiers in Immunology·2021· 25 citedOpen Access
Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
PLoS Pathogens·2021· 29 citedOpen Access
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
Science·2021· 56 citedOpen Access
Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy
Science Immunology·2021· 53 citedOpen Access
Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy
2021· 1 citedOpen Access
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome
PLoS Pathogens·2020· 36 citedOpen Access
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
2020· 9 citedOpen Access
Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy
2020· 3 citedOpen Access
<i>In vitro</i> and <i>in vivo</i> characterization of a recombinant rhesus cytomegalovirus containing a complete genome
2020· 2 citedOpen Access
Characterization of a live-attenuated HCMV-based vaccine platform
Scientific Reports·2019· 42 citedOpen Access
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge
Science Translational Medicine·2019· 110 cited
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Frequent Co-authors

Scott G. Hansen(32), Louis J. Picker(31), Roxanne M. Gilbride(24), Klaus Früh(24), Michael K. Axthelm(23), Julia C. Ford(21), Daniel Malouli(21), Abigail B. Ventura(20), Paul T. Edlefsen(18), Jeffrey D. Lifson(17), David Morrow(17), Jonah B. Sacha(16), Rebecca Shoemaker(15), Alfred W. Legasse(12), Andrea N. Selseth(12), Jay A. Nelson(10), William J. Bosche(10), Husam Taher(10), Kelli Oswald(9), Jason S. Reed(9)