Alexandros Makriyannis

Northeastern University — United States

Medicine · Health Sciences

85h-index27.8kcitations576works3.92yr avg
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Research Topics

Cannabis and Cannabinoid Research(410), Neurotransmitter Receptor Influence on Behavior(146), Neuroscience and Neuropharmacology Research(131), Forensic Toxicology and Drug Analysis(70), Pharmacological Receptor Mechanisms and Effects(55)

Publications575 total

Effects of the Neutral CB1 Receptor Antagonist AM6527 on Spontaneous, Consummatory, and Motivated Behavior in Mice
2025Open Access
Exceptionally Potent Chiral Anandamide Analogs
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature·2025· 3 citedOpen Access
Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature·2025Open Access
Novel Tetraolefinic Chain Phenyl Substituted Endocannabinoid Probes
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Acetaminophen attenuates pathological pain through a mechanism that requires CB1 cannabinoid receptors and the enzyme diacylglycerol lipase in mice
2025· 1 citedOpen Access
CB1 cannabinoid receptor agonists induce acute respiratory depression in awake mice
Pharmacological Research·2025· 3 citedOpen Access
Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects
Nature Communications·2025· 9 citedOpen Access
Effects of Cannabinoid (CB) 1 Receptor Neutral Antagonists on Fentanyl-Induced Conditioned Place Preference and Antinociception (Abstract ID: 164640)
Journal of Pharmacology and Experimental Therapeutics·2025
Neurochemical and Behavioral Effects of Cannabinoid CB1 Agonist in Male Mice
Drug and Alcohol Dependence·2025
Structural basis of THC analog activity at the Cannabinoid 1 receptor
Nature Communications·2025· 10 citedOpen Access
Pharmacological Inhibition of <i>N</i>-Acylethanolamine Acid Amidase (NAAA) Mitigates Intestinal Fibrosis Through Modulation of Macrophage Activity
Journal of Crohn s and Colitis·2024· 6 citedOpen Access
Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations
Receptors·2024· 4 citedOpen Access
Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance
Biomedicine & Pharmacotherapy·2024· 8 citedOpen Access
Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2
ACS Medicinal Chemistry Letters·2024· 6 citedOpen Access
Neurochemical and Behavioral Effects of Cannabinoid CB1 Agonist in Male Mice
Journal of Pharmacology and Experimental Therapeutics·2024
AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects
Neuropsychopharmacology·2024· 11 citedOpen Access
Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target
ACS Chemical Biology·2024· 22 citedOpen Access
P2X<sub>7</sub> receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism
British Journal of Pharmacology·2024· 4 citedOpen Access
CB <sub>1</sub> Cannabinoid Receptor Agonists Induce Acute Respiratory Depression in Awake Mice
2024· 1 citedOpen Access
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Frequent Co-authors

Atmaram D. Khanolkar(7), Daniele Piomelli(6), Kiran Vemuri(6), George Kunos(6), Tian Hua(5), Mohab Ibrahim(5), Frank Porreca(5), Todd W. Vanderah(5), Heriberto P. Mata(5), Andrea G. Hohmann(5), Vincenzo Di Marzo(4), Yiran Wu(4), Suwen Zhao(4), Nikolai Zvonok(4), Laura Bohn(4), Zhi‐Jie Liu(4), Spyros P. Nikas(4), Pusheng Fan(4), Sonyuan Lin(4), Roger G. Pertwee(4)