Lars Aagaard

Aarhus University — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.2kcitations57works4.02yr avg
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Research Topics

RNA Interference and Gene Delivery(19), Virus-based gene therapy research(17), CRISPR and Genetic Engineering(13), Advanced biosensing and bioanalysis techniques(12), MicroRNA in disease regulation(11)

Publications57 total

Nanobody-based gene therapy targeting complement component C3 reduces choroidal neovascularization in mice
Molecular Therapy — Methods & Clinical Development·2025· 1 citedOpen Access
Lineær IgA-dermatose
Ugeskrift for Læger·2024Open Access
MikroRNA: en revolutionerende opdagelse i genregulering
Ugeskrift for Læger·2024Open Access
Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model
Molecular Therapy — Methods & Clinical Development·2024· 15 citedOpen Access
25 years of maturation: A systematic review of RNAi in the clinic
Molecular Therapy — Nucleic Acids·2023· 47 citedOpen Access
Sustained secretion of human growth hormone from TheraCyte devices encapsulated with PiggyBac-engineered retinal pigment epithelium cells
Tissue and Cell·2023· 2 citedOpen Access
An Extended PD-L2 Cytoplasmic Domain Results From Alternative Splicing in NSCLC Cells
Journal of Immunotherapy·2022· 6 cited
Animal Models of Choroidal Neovascularization: A Systematic Review
Investigative Ophthalmology & Visual Science·2022· 36 citedOpen Access
Simple Autofluorescence-Restrictive Sorting of eGFP+ RPE Cells Allows Reliable Assessment of Targeted Retinal Gene Therapy
Frontiers in Drug Delivery·2022· 10 citedOpen Access
VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy
Molecular Therapy — Nucleic Acids·2022· 16 citedOpen Access
Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis
Molecular Therapy·2021· 24 citedOpen Access
Variants in the <scp>ethylmalonyl‐CoA</scp> decarboxylase (<scp><i>ECHDC1</i></scp>) gene: a novel player in ethylmalonic aciduria?
Journal of Inherited Metabolic Disease·2021· 7 citedOpen Access
Methylation silencing and reactivation of exogenous genes in lentivirus-mediated transgenic mice
Transgenic Research·2021· 5 cited
Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation
Stem Cells International·2020· 9 citedOpen Access
MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides
Acta Dermato Venereologica·2020· 8 citedOpen Access
Gene Therapy for eAMD by Lentiviral Delivery of Dicer-Independent shRNAs Providing Increased Specificity and Safety
Investigative Ophthalmology & Visual Science·2019Open Access
Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy
Molecular Therapy — Nucleic Acids·2019· 64 citedOpen Access
Efficient Knockdown and Lack of Passenger Strand Activity by Dicer-Independent shRNAs Expressed from Pol II-Driven MicroRNA Scaffolds
Molecular Therapy — Nucleic Acids·2018· 18 citedOpen Access
Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs
Molecular Therapy — Nucleic Acids·2018· 13 citedOpen Access
Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein
Molecular Therapy — Nucleic Acids·2018· 40 citedOpen Access
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Frequent Co-authors

Thomas J. Corydon(17), Anne Louise Askou(14), Jacob Giehm Mikkelsen(13), John J. Rossi(9), Thomas G. Jensen(9), Sidsel Alsing(7), Toke Bek(7), Finn Skou Pedersen(6), Christian Kroun Damgaard(6), Emilie Grarup Jensen(5), Cláudia R. Cecchi(5), Pål Sætrom(4), Yan Zhou(4), Yonglun Luo(4), Thomas Stax Jakobsen(4), Ali A. Ehsani(3), Palle Villesen(3), Lars Bolund(3), Olof Pettersson(3), Josephine Natalia Esther Benckendorff(3)