Jacob Giehm Mikkelsen

Aarhus University — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index6.0kcitations168works4.32yr avg
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Research Topics

CRISPR and Genetic Engineering(68), Virus-based gene therapy research(58), RNA Interference and Gene Delivery(48), interferon and immune responses(20), Animal Genetics and Reproduction(16)

Publications168 total

Mechanical stretch regulates inflammatory signaling in human smooth muscle cells
2025Open Access
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor
Nature Immunology·2025· 6 cited
Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans
The Journal of Experimental Medicine·2025
PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP
Biomarker Research·2025· 3 citedOpen Access
CXCR2 deficiency with myelokathexis caused by a novel variant: correction via CRISPR/Cas9
Haematologica·2025Open Access
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease
Nature Communications·2025Open Access
Gene editing in hematopoietic stem cells by co-delivery of Cas9/sgRNA ribonucleoprotein and templates for homology-directed repair in ‘all-in-one’ lentivirus-derived nanoparticles
Nucleic Acids Research·2025· 2 citedOpen Access
Treatment of GATA2 deficiency by allele-specific CRISPR-Cas9-directed gene correction in hematopoietic stem cells
Molecular Therapy·2025
Multiparametric Optimization of Human Primary B‐Cell Cultures Using Design of Experiments
Scandinavian Journal of Immunology·2025· 1 citedOpen Access
CRISPR/Cas gene editing of haematopoietic stem cells for curing primary immunodeficiency
Ugeskrift for Læger·2025Open Access
Trojan Horse-Like Vehicles for CRISPR-Cas Delivery: Engineering Extracellular Vesicles and Virus-Like Particles for Precision Gene Editing in Cystic Fibrosis
Human Gene Therapy·2025· 4 citedOpen Access
Abstract 5171: Development of preclinical models of NTRK fusion-driven cancers
Cancer Research·2025
Multiparametric optimization of human primary B-cell cultures using Design of Experiments
2025· 1 cited
Early host defense against virus infections
Cell Reports·2024· 13 citedOpen Access
Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles
Molecular Therapy — Nucleic Acids·2024· 10 citedOpen Access
Gene Editing by Ferrying of CRISPR/Cas Ribonucleoprotein Complexes in Enveloped Virus-Derived Particles
Human Gene Therapy·2024· 5 cited
TMEFF1 is a neuron-specific restriction factor for herpes simplex virus
Nature·2024· 22 cited
SAM68 directs STING signaling to apoptosis in macrophages
Communications Biology·2024· 6 citedOpen Access
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis
Journal of Clinical Immunology·2024· 9 citedOpen Access
STING activation counters glioblastoma by vascular alteration and immune surveillance
Cancer Letters·2023· 21 citedOpen Access
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Frequent Co-authors

Rasmus O. Bak(14), Søren R. Paludan(10), Thomas J. Corydon(9), Brian Moldt(8), Trine H. Mogensen(7), Anne Kruse Hollensen(7), Frederik Dagnæs‐Hansen(7), Anne Louise Askou(7), Kristian Alsbjerg Skipper(6), Martin K. Thomsen(6), Stephen R. Yant(5), Mark A. Kay(5), Nicklas Heine Staunstrup(5), Thomas G. Jensen(5), Toke Bek(5), Maria Jakobsen(4), Rune Hartmann(4), Mogens Duch(4), P. M. Kragh(4), Mette Schmidt(4)