Rasmus O. Bak

Aarhus University — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index8.3kcitations130works4.12yr avg
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Research Topics

CRISPR and Genetic Engineering(66), Virus-based gene therapy research(31), RNA Interference and Gene Delivery(26), CAR-T cell therapy research(21), Pluripotent Stem Cells Research(12)

Publications130 total

Cholesterol Biosynthesis is a Targetable Vulnerability of <i>CEBPA</i> -mutant Acute Myeloid Leukemia
2026Open Access
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor
Nature Immunology·2025· 6 cited
CXCR2 deficiency with myelokathexis caused by a novel variant: correction via CRISPR/Cas9
Haematologica·2025Open Access
Orthogonal CRISPR systems for targeted integration and multiplex base editing enable nonviral engineering of allogeneic CAR-T cells
Molecular Therapy·2025· 4 citedOpen Access
Editing of <i>ADA2</i> Point Mutation in Human Hematopoietic Stem Cells
2025Open Access
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease
Nature Communications·2025Open Access
Gene editing in hematopoietic stem cells by co-delivery of Cas9/sgRNA ribonucleoprotein and templates for homology-directed repair in ‘all-in-one’ lentivirus-derived nanoparticles
Nucleic Acids Research·2025· 2 citedOpen Access
Treatment of GATA2 deficiency by allele-specific CRISPR-Cas9-directed gene correction in hematopoietic stem cells
Molecular Therapy·2025
Development of a Gene Editing Platform to Enhance CAR-T Therapy Through Inducible IL-15 Expression at the PD-1 Locus
2025Open Access
Corrigendum: Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells
Frontiers in Immunology·2025Open Access
CRISPR/Cas gene editing of haematopoietic stem cells for curing primary immunodeficiency
Ugeskrift for Læger·2025Open Access
Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cells
Molecular Therapy — Nucleic Acids·2025· 5 citedOpen Access
Abstract 5861: Characterizing an immune synapse between plasmacytoid dendritic cells and cancer cells that drives cancer cytotoxicity
Cancer Research·2025
Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells
Frontiers in Immunology·2025Open Access
Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells
Cell Reports·2025· 3 citedOpen Access
Characterization of the role of spatial proximity of DNA double-strand breaks in the formation of CRISPR-Cas9-induced large structural variations
Genome Research·2025Open Access
Integration of large genetic payloads using prime editing and site-specific integrases
Nature Protocols·2024· 1 cited
Orthogonal transcriptional modulation and gene editing using multiple CRISPR-Cas systems
Molecular Therapy·2024· 7 citedOpen Access
417 Design of programmable immune reactive cells (PIRCs) with precision type I interferon and cytotoxicity response in solid tumors
Regular and Young Investigator Award Abstracts·2024Open Access
Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells
2024
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Frequent Co-authors

Matthew H. Porteus(18), Jacob Giehm Mikkelsen(18), Daniel P. Dever(10), Joab Camarena(8), Anders Laustsen(8), Martin R. Jakobsen(6), Søren R. Paludan(5), M. Kyle Cromer(5), Nanna S. Mikkelsen(5), Ciaran M. Lee(4), Natalia Gomez‐Ospina(4), Gang Bao(4), Martin K. Thomsen(4), Renata M. Martin(4), Zongliang Gao(4), Yujia Cai(4), Trine I. Jensen(4), Anne Kruse Hollensen(4), Ayal Hendel(3), Andreas Reinisch(3)