Ciaran M. Lee

National University of Ireland — Ireland

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index6.2kcitations84works2.72yr avg
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Research Topics

CRISPR and Genetic Engineering(56), Virus-based gene therapy research(22), RNA and protein synthesis mechanisms(15), CAR-T cell therapy research(10), Hemoglobinopathies and Related Disorders(9)

Publications84 total

A <scp>CRISPRi</scp> Gene Regulation System for Bifidobacteria
Microbial Biotechnology·2025· 1 citedOpen Access
246 Design of a fluorescent compound heterozygote reporter cell line to interrogate gene conversion with allele-specific nicks using Cas9 nickase – towards correction of compound heterozygous CF genotypes
Journal of Cystic Fibrosis·2025
256 Correct me if I’m wrong: conversion of CFTR variants in compound heterozygous cell lines
Journal of Cystic Fibrosis·2025
Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of BMP-NOGGIN Axis
2025Open Access
Genetic Characterisation of the <i>upp</i> Gene in <i>Bifidobacterium bifidum</i> PRL2010
Microbial Biotechnology·2025Open Access
Improving resolution with single-cell detection of CRISPR off-target events
Molecular Therapy — Methods & Clinical Development·2025Open Access
IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19
2025Open Access
Tu1188: INHIBITION OF JAK/STAT SIGNALLING ATTENUATES NSAID-INDUCED INTESTINAL INFLAMMATION AND CELL DEATH
Gastroenterology·2025
An Overview and Comparative Analysis of CRISPR-SpCas9 gRNA Activity Prediction Tools
The CRISPR Journal·2025· 2 citedOpen Access
Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells
2025Open Access
Pseudocin 196, a novel lantibiotic produced by <i>Bifidobacterium pseudocatenulatum</i> elicits antimicrobial activity against clinically relevant pathogens
Gut Microbes·2024· 7 citedOpen Access
Two extracellular α-arabinofuranosidases are required for cereal-derived arabinoxylan metabolism by <i>Bifidobacterium longum</i> subsp. <i>longum</i>
Gut Microbes·2024· 8 citedOpen Access
Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome
Molecular Therapy — Methods & Clinical Development·2024· 7 citedOpen Access
<scp>GH136</scp> ‐encoding gene ( <scp> <i>per</i> B </scp> ) is involved in gut colonization and persistence by <i>Bifidobacterium bifidum</i> <scp>PRL2010</scp>
Microbial Biotechnology·2024· 13 citedOpen Access
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes
The CRISPR Journal·2022· 18 citedOpen Access
High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells
The CRISPR Journal·2022· 23 citedOpen Access
Identification and Validation of CRISPR/Cas9 Off-Target Activity in Hematopoietic Stem and Progenitor Cells
Methods in molecular biology·2022· 3 citedOpen Access
In vivo genome editing at the albumin locus to treat methylmalonic acidemia
Molecular Therapy — Methods & Clinical Development·2021· 19 citedOpen Access
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
Cell Death and Disease·2021· 165 citedOpen Access
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease
Science Translational Medicine·2021· 150 citedOpen Access
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Frequent Co-authors

Gang Bao(41), Matthew H. Porteus(14), Timothy Davis(7), Thomas J. Cradick(7), Volker Wiebking(6), William R. Lagor(6), Waracharee Srifa(6), Mara Pavel-Dinu(5), Kelsey E. Jarrett(5), Sruthi Mantri(5), Maria Grazia Roncarolo(5), Daniel P. Dever(4), Joab Camarena(4), So Hyun Park(4), Rasmus O. Bak(4), Ayrea Hurley(4), Harshavardhan Deshmukh(4), Marco De Giorgi(3), Alexandria M. Doerfler(3), Beruh Dejene(3)