Daniel P. Dever

Fondazione GraphiTech — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index4.6kcitations66works8.52yr avg
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Research Topics

CRISPR and Genetic Engineering(42), Hemoglobinopathies and Related Disorders(13), Virus-based gene therapy research(11), Cytomegalovirus and herpesvirus research(9), Mosquito-borne diseases and control(6)

Publications66 total

A differentiated β-globin gene replacement strategy uses heterologous introns to restore physiological expression
Molecular Therapy·2025· 2 citedOpen Access
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis
Blood·2024· 1 citedOpen Access
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
Nature Communications·2024· 6 citedOpen Access
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells
Nature Communications·2024· 25 citedOpen Access
Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
2023Open Access
Development of a β-Globin Gene Replacement Strategy As a β-Thalassemia Therapy
Blood·2022
Cedar Trial in Progress: A First in Human, Phase 1/2 Study of the Correction of a Single Nucleotide Mutation in Autologous HSCs (GPH101) to Convert HbS to HbA for Treating Severe SCD
Blood·2021· 20 cited
Reticular Dysgenesis-Associated Adenylate Kinase 2 Deficiency Impairs Purine Metabolism and Ribosomal Biogenesis during Myelopoiesis
Blood·2021
3017 – ESTABLISHMENT OF A PLATFORM FOR EX VIVO GENE EDITING IN MULTIPOTENT HEMATOPOIETIC STEM CELLS
Experimental Hematology·2021
Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism
2021· 3 citedOpen Access
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease
Science Translational Medicine·2021· 150 citedOpen Access
Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency
Molecular Therapy — Methods & Clinical Development·2021· 24 citedOpen Access
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
Nature Medicine·2021· 80 citedOpen Access
Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice
Nature Communications·2021· 97 citedOpen Access
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells
Nature Communications·2021· 29 citedOpen Access
Clinically Relevant Gene Editing in Hematopoietic Stem Cells for the Treatment of Pyruvate Kinase Deficiency Hemolytic Anemia
2021Open Access
Correction of the Energetic Defects in Pyruvate Kinase Deficiency through Genome Editing in Hematopoietic Stem and Progenitor Cells
Blood·2020
Reticular Dysgenesis-Associated Adenylate Kinase 2 Deficiency Impairs Hematopoietic Stem and Progenitor Cell Function through Reductive Stress
Blood·2020
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
2020· 3 citedOpen Access
Cas9-AAV6 Gene Correction of Beta-Globin in Autologous HSCs Improves Sickle Cell Disease Erythropoiesis in Mice
2020· 12 citedOpen Access
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Frequent Co-authors

Matthew H. Porteus(36), Joab Camarena(24), Rasmus O. Bak(15), Ravindra Majeti(9), Carsten T. Charlesworth(8), M. Kyle Cromer(8), Christopher A. Vakulskas(7), Mara Pavel-Dinu(7), Ciaran M. Lee(7), Gang Bao(7), Renata M. Martin(6), Hiromitsu Nakauchi(6), Mark A. Behlke(5), Andreas Reinisch(5), Nobuko Uchida(5), Adam C. Wilkinson(5), Ron Baik(5), Viktor T. Lemgart(4), Benjamin J. Lesch(4), Natalia Gomez‐Ospina(4)