Carsten T. Charlesworth

California Institute for Regenerative Medicine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index1.7kcitations30works4.82yr avg
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Research Topics

CRISPR and Genetic Engineering(21), Virus-based gene therapy research(6), Erythropoietin and Anemia Treatment(6), RNA Interference and Gene Delivery(4), CAR-T cell therapy research(4)

Publications30 total

FLT3 ligand facilitates long-term ex vivo expansion of human hematopoietic stem cells by maintaining lymphoid reconstitution potential
Blood·2025Open Access
Xenophagocytosis blockade enhances interspecies chimerism
2025Open Access
GFP-on mouse model for interrogation of in vivo gene editing
Nature Communications·2025Open Access
Highly efficient in vivo hematopoietic stem cell transduction using an optimized self-complementary adeno-associated virus
Molecular Therapy — Methods & Clinical Development·2025· 2 citedOpen Access
Combining HSC Base-Editing with Anti-CD117 Antibody Conditioning to Correct Severe Combined Immunodeficiency Disorder in a Novel Mouse Model
Transplantation and Cellular Therapy·2025
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
Nature Communications·2025· 5 citedOpen Access
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
2024Open Access
Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic Engineering
2024· 1 citedOpen Access
3133 – HYPOXIC/SCF-SUPPLEMENTED CULTURE IN POLYMER-BASED MEDIUM ENABLES STABLE EX VIVO HUMAN HEMATOPOIETIC STEM CELL EXPANSION
Experimental Hematology·2024
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells
Nature Biomedical Engineering·2024· 8 citedOpen Access
Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
2024Open Access
Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
2024Open Access
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
Nature Biotechnology·2024· 47 citedOpen Access
Secreted Particle Information Transfer (SPIT) – A Cellular Platform for <i>In Vivo</i> Genetic Engineering
2024· 4 citedOpen Access
Using Human Genetics to Develop Strategies to Increase Erythropoietic Output from Genome-Edited Hematopoietic Stem and Progenitor Cells
Blood·2023Open Access
Using human genetics to develop strategies to increase erythropoietic output from genome-edited hematopoietic stem and progenitor cells
2023· 5 citedOpen Access
An optimized Sendai viral vector platform for reprogramming to naive pluripotency
Cell Reports Methods·2022· 1 citedOpen Access
Author Correction: Investigation of Cas9 antibodies in the human eye
Nature Communications·2022· 2 citedOpen Access
Immunological barriers to haematopoietic stem cell gene therapy
Nature reviews. Immunology·2022· 59 citedOpen Access
Investigation of Cas9 antibodies in the human eye
Nature Communications·2022· 25 citedOpen Access
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Frequent Co-authors

Matthew H. Porteus(18), Joab Camarena(14), Hiromitsu Nakauchi(14), M. Kyle Cromer(11), Daniel P. Dever(9), Fabian P. Suchy(8), Adam C. Wilkinson(7), Sofia E. Luna(7), Kiran R. Majeti(7), Eric Soupène(7), Jinyu Zhang(6), Sridhar Selvaraj(6), Benjamin J. Lesch(5), Ian Hsu(5), Joydeep Bhadury(5), Shota Homma(5), Ron Baik(4), Chika Morita(4), Aadit P. Shah(4), Freja K. Ekman(4)