Viktor T. Lemgart

AVEO Oncology (United States) — United States

Medicine · Health Sciences

4h-index1.2kcitations11works1.02yr avg
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Research Topics

Hemoglobinopathies and Related Disorders(5), Iron Metabolism and Disorders(4), CRISPR and Genetic Engineering(4), CAR-T cell therapy research(4), Epigenetics and DNA Methylation(3)

Publications11 total

Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies
Molecular Therapy·2026
Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway
Science Advances·2025Open Access
Abstract 6119: Efficient generation of active CAR-T cells from healthy donors and lymphoma patients
Cancer Research·2025
In Vitro and In Vivo Activity of a Lipid Nanoparticle System for the In Vivo Generation of CAR T Cells
Blood·2024· 4 citedOpen Access
Genomic discovery and functional validation of MRP1 as a novel fetal hemoglobin modulator and potential therapeutic target in sickle cell disease
2023· 3 citedOpen Access
SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells
Blood Advances·2023· 3 citedOpen Access
<i>Inhibition of MRP1 Induces Fetal Hemoglobin through NRF2 Activation to Protect Human Erythroid Cells from Sickling</i>
Blood·2022
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
Nature Medicine·2021· 80 citedOpen Access
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
2020· 3 citedOpen Access
Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination
Cell stem cell·2019· 213 citedOpen Access
Identification of preexisting adaptive immunity to Cas9 proteins in humans
Nature Medicine·2019· 924 citedOpen Access

Frequent Co-authors

Daniel P. Dever(4), Joab Camarena(4), M. Kyle Cromer(4), Benjamin J. Lesch(4), Matthew H. Porteus(4), Yannis Hara(4), Alexandra Hicks(4), Samuel Lessard(4), Christopher A. Vakulskas(3), Renata M. Martin(3), Rasmus O. Bak(3), Laura Strauss(3), Brandon Quido(3), Eyoung Shin(3), Austin W. Boesch(3), Dharini Shah(3), Tiffany Le(3), Rasika D Kunden(3), Fazila Nasimi(3), Sampa Maiti(3)