Isabelle Plo

Inserm — France

Medicine · Health Sciences

43h-index8.9kcitations276works2.12yr avg
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Research Topics

Myeloproliferative Neoplasms: Diagnosis and Treatment(150), Chronic Myeloid Leukemia Treatments(73), Acute Myeloid Leukemia Research(71), Kruppel-like factors research(41), Eosinophilic Disorders and Syndromes(35)

Publications276 total

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors
Cell Reports·2025Open Access
Telomere occupancy by TRF2 is altered by KIT mutations and correlates with mastocytosis regression
Blood Cancer Journal·2025Open Access
Extracellular matrix-targeting oligonucleotide reverses marrow fibrosis
Blood·2025Open Access
Mitochondrial dysfunction as a key factor in the predisposition to 14q32-related myeloid hematological malignancies
Blood·2025Open Access
IFN-I-Mediated Transcriptional Reprogramming Drives Myeloid-skewed Hematopoiesis in Sickle Cell Anemia
2025Open Access
MODELAGEM DA MUTAÇÃO TP53R175H EM IPSC DERIVADA DE NEOPLASIA MIELOPROLIFERATIVA COM CALRDEL52
Hematology Transfusion and Cell Therapy·2025Open Access
Dissecting JAK2V617F’s double life with and without MPL
Blood·2025Open Access
JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms
Nature Communications·2025· 3 citedOpen Access
Expanding the phenotypic and genetic landscape of congenital neutropenia through whole‐exome and genome sequencing
HemaSphere·2025· 1 citedOpen Access
Type 2 calreticulin mutations activate ATF6 to promote BCL-xL–mediated survival in myeloproliferative neoplasms
Blood·2025· 2 citedOpen Access
Identification of Hepatic-like EPO as a Cause of Polycythemia
New England Journal of Medicine·2025· 10 cited
Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome
Haematologica·2025Open Access
Monocytes generated by interleukin-6-treated human hematopoietic stem and progenitor cells secrete calprotectin that inhibits erythropoiesis
iScience·2024· 1 citedOpen Access
Identification of Hepatic-like Erythropoietin with Enhanced Activity As a New Cause of Hereditary and Acquired Erythrocytosis
Blood·2024· 1 cited
Amplification of Von Willebrand Factor-Positive <i>CALRmut</i> Disease-Initiating Hematopoietic Stem Cells Is Associated to the Activation of the PERK/EiF2a Branch of Unfolded Protein Response
Blood·2024Open Access
New approaches to standard of care in early-phase myeloproliferative neoplasms: can interferon-α alter the natural history of the disease?
Haematologica·2024· 3 citedOpen Access
COOPERAÇÃO DAS MUTAÇÕES CALR E TP53 NA TRANSFORMAÇÃO LEUCÊMICA DAS NEOPLASIAS MIELOPROLIFERATIVAS
Hematology Transfusion and Cell Therapy·2024Open Access
Impaired fibrinolysis in JAK2V617F-related myeloproliferative neoplasms
Journal of Thrombosis and Haemostasis·2024· 3 citedOpen Access
Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN
Blood·2024· 21 citedOpen Access
Mathematical modelling, selection and hierarchical inference to determine the minimal dose in IFNα therapy against myeloproliferative neoplasms
Mathematical Medicine and Biology A Journal of the IMA·2024
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Frequent Co-authors

William Vainchenker(35), Caroline Marty(18), Stefan N. Constantinescu(16), Éric Solary(13), Hana Raslová(10), Najet Debili(9), C. Pecquet(8), Róbert Královics(8), Nicole Casadevall(7), Olivier Bernard(7), Ilyas Chachoua(6), Jean‐Philippe Defour(6), Florence Pasquier(6), Nathalie Droin(6), Christine Bellanné‐Chantelot(6), François Delhommeau(5), Christophe Marzac(5), Harini Nivarthi(5), Jean‐Luc Villeval(5), Rémi Favier(5)