Barry S. Cooperman

California University of Pennsylvania — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index8.9kcitations322works0.32yr avg
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Research Topics

RNA and protein synthesis mechanisms(163), RNA modifications and cancer(89), ATP Synthase and ATPases Research(47), Bacterial Genetics and Biotechnology(37), RNA Research and Splicing(31)

Publications322 total

Near-cognate tRNAs enhance tRNA rejection and prime the ribosome for rapid subsequent tRNA testing
Biophysical Journal·2025Open Access
EPS3.01CFTR rescue in a G542X nonsense mouse model of cystic fibrosis: investigating the mechanism of action and activity of translational readthrough-inducing drugs
Journal of Cystic Fibrosis·2025
Suppression of nonsense mutations by small, cyclic peptides
2025Open Access
Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases
Nucleic Acids Research·2025· 2 citedOpen Access
BPS2025 - Developing a method for screening inhibitors of RFC-dependent termination of protein synthesis at PTCs
Biophysical Journal·2025
BPS2025 - Coupling among reaction steps in termination of eukaryotic peptide synthesis
Biophysical Journal·2025Open Access
Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases
2024Open Access
Single-Molecule Studies of Cognate and Near-Cognate Elongation in an <i>in vitro</i> Eukaryotic Translation System
2024· 1 citedOpen Access
High termination activity negatively influences nonsense suppression
Biophysical Journal·2024Open Access
Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins
Genome Research·2023· 13 citedOpen Access
Influence of mRNA sequences downstream of a premature stop codon on nonsense suppression
Biophysical Journal·2023
Translational readthrough-inducing drug (TRID) effects on eukaryotic termination investigated at the single-molecule level
Biophysical Journal·2023
A High-Throughput Assay for In Vitro Determination of Release Factor-Dependent Peptide Release from a Pretermination Complex by Fluorescence Anisotropy—Application to Nonsense Suppressor Screening and Mechanistic Studies
Biomolecules·2023· 4 citedOpen Access
Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins
2023Open Access
Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria
Nucleic Acids Research·2023· 33 citedOpen Access
Human mitochondria require mtRF1 for translation termination at non-canonical stop codons
Nature Communications·2023· 34 citedOpen Access
Data for "Single-Molecule Studies of Cognate and Near-Cognate Elongation in an <i>in vitro</i> Eukaryotic Translation System".
Figshare·2023Open Access
Assembly of the Mitochondrial Translation Initiation Complex
Methods in molecular biology·2023· 2 cited
Ataluren binds to multiple protein synthesis apparatus sites and competitively inhibits release factor-dependent termination
Nature Communications·2022· 44 citedOpen Access
Ataluren Binds to Multiple Protein Synthesis Apparatus Sites and Competitively Inhibits Release Factor Dependent Termination
Research Square (Research Square)·2022· 1 citedOpen Access
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Frequent Co-authors

Reijo Lahti(9), Harvey Rubin(9), Alexander A. Baykov(8), Adrian Goldman(8), Yale E. Goldman(7), Dongli Pan(6), Chunlai Chen(4), Pirkko Heikinheimo(4), Z M Wang(3), Elliot Nickbarg(3), Norman M. Schechter(3), Tiina A. Salminen(3), Jussi Kankare(3), S.V. Kirillov(2), David W. Christianson(2), O L Schoenberger(2), Josphin Johnson(2), Haibo Zhang(2), Ian Farrell(2), Benjamin Stevens(2)