Kebing Yu

Digital Proteomics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.5kcitations51works6.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(14), Advanced Proteomics Techniques and Applications(9), Protein Kinase Regulation and GTPase Signaling(6), Cell death mechanisms and regulation(5), Mitochondrial Function and Pathology(5)

Publications51 total

Development of a bispecific antibody that inhibits EGFR and B7H3 in NSCLC
Biomarker Research·2025Open Access
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
Cell chemical biology·2025· 1 cited
An RNA damage response network mediates the lethality of 5-FU in colorectal cancer
Cell Reports Medicine·2024· 27 citedOpen Access
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
2024Open Access
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2
Science Signaling·2024· 2 citedOpen Access
AzidoTMT Enables Direct Enrichment and Highly Multiplexed Quantitation of Proteome-Wide Functional Residues
Journal of Proteome Research·2023· 9 citedOpen Access
An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types
2023· 7 citedOpen Access
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry
Analytical Chemistry·2023· 12 cited
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action
Journal of Biological Chemistry·2022· 1 citedOpen Access
Selective activation of PFKL suppresses the phagocytic oxidative burst
Cell·2021· 150 citedOpen Access
Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein
Journal of the American Chemical Society·2021· 16 cited
Chaperone mediated detection of small molecule target binding in cells
Nature Communications·2020· 14 citedOpen Access
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
Nature·2019· 87 cited
Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis
Journal of Proteome Research·2018· 22 citedOpen Access
Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors
Cancer Research·2018
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
Nature Communications·2018· 86 citedOpen Access
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Molecular Cell·2018· 116 citedOpen Access
USP7 small-molecule inhibitors interfere with ubiquitin binding
Nature·2017· 332 citedOpen Access
Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
Cell Death and Differentiation·2016· 121 citedOpen Access
Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death
Molecular & Cellular Proteomics·2016· 9 citedOpen Access
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Frequent Co-authors

Arthur R. Salomon(20), Donald S. Kirkpatrick(10), William F. Forrest(8), Ingrid E. Wertz(8), Anita Izrael-Tomasevic(8), P. Taylur(7), Wayne J. Fairbrother(6), Domagoj Vucic(6), Lulu Cao(6), Robert A. Blake(5), Kim Newton(5), Tatiana Goncharov(5), Icksoo Lee(5), Maik Hüttemann(5), Jennie R. Lill(5), Christopher M. Rose(5), Lorna Kategaya(4), Tracy Kleinheinz(4), Frank Peale(4), Wendy Sandoval(4)