Kim Newton

Genentech

Biochemistry, Genetics and Molecular Biology · Life Sciences

58h-index21.9kcitations121works56.12yr avg
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Research Topics

Cell death mechanisms and regulation(39), Inflammasome and immune disorders(28), Ubiquitin and proteasome pathways(22), interferon and immune responses(22), NF-κB Signaling Pathways(15)

Publications120 total

cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A
Cell Death and Differentiation·2025Open Access
Author Correction: Activity of caspase-8 determines plasticity between cell death pathways
Nature·2025Open Access
Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Nature·2025Open Access
Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Nature·2025Open Access
Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors
Nature Immunology·2025
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
Nature·2025Open Access
IRF2 degradation tunes the innate immune response
2025Open Access
COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway
Cells·2025· 1 citedOpen Access
Impairment of DET1 causes neurological defects and lethality in mice and humans
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis
2025· 1 citedOpen Access
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture
Nature·2024· 40 citedOpen Access
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
Immunity·2024· 23 citedOpen Access
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
Cell Death and Differentiation·2024· 24 citedOpen Access
Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis
Cell Death and Differentiation·2024· 11 citedOpen Access
Cell death
Cell·2024· 737 citedOpen Access
Control of Cell Death in Health and Disease
Annual Review of Pathology Mechanisms of Disease·2023· 99 citedOpen Access
Targeted alveolar regeneration with Frizzled-specific agonists
Cell·2023· 75 citedOpen Access
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Nature·2023· 150 citedOpen Access
XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death
Cell Death and Disease·2023· 8 citedOpen Access
Deubiquitinases in cell death and inflammation
Biochemical Journal·2022· 21 citedOpen Access
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Frequent Co-authors

Vishva M. Dixit(34), Joshua D. Webster(18), Debra L. Dugger(13), Merone Roose‐Girma(11), Wyne P. Lee(10), Nobuhiko Kayagaki(10), Jinfeng Liu(8), Donald S. Kirkpatrick(8), Allie Maltzman(8), Domagoj Vucic(7), Andreas Strasser(7), Søren Warming(6), Dorothy French(6), László G. Kömüves(6), Jennie R. Lill(6), Zora Modrušan(6), Rohit Reja(6), Denise M. Monack(5), Yan Qu(5), Katherine E. Wickliffe(5)