Rohit Reja

Acentech (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index3.1kcitations35works5.12yr avg
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Research Topics

RNA Research and Splicing(7), Immune Response and Inflammation(6), Inflammasome and immune disorders(6), RNA and protein synthesis mechanisms(5), Cell death mechanisms and regulation(4)

Publications35 total

cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A
Cell Death and Differentiation·2025Open Access
Author Correction: Activity of caspase-8 determines plasticity between cell death pathways
Nature·2025Open Access
Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors
Nature Immunology·2025
Transcription factor Zfx regulates tumor’s evasion to T cell killing in immunotherapy
iScience·2025Open Access
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
Nature·2025Open Access
IRF2 degradation tunes the innate immune response
2025Open Access
Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells
2025Open Access
COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway
Cells·2025· 1 citedOpen Access
Seed sequences mediate off-target activity in the CRISPR-interference system
Cell Genomics·2024· 11 citedOpen Access
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
Immunity·2024· 23 citedOpen Access
Seed sequences mediate off-target activity in the CRISPR-interference (CRISPRi) system
2024· 1 citedOpen Access
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
Cell Death and Differentiation·2024· 24 citedOpen Access
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection
Cell Host & Microbe·2021· 175 citedOpen Access
NINJ1 mediates plasma membrane rupture during lytic cell death
Nature·2021· 738 cited
Integration of innate immune signalling by caspase-8 cleavage of N4BP1
Nature·2020· 109 cited
Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription
Cell Reports·2020· 14 citedOpen Access
NINJ1 mediates plasma membrane rupture during lytic cell death
2020· 23 citedOpen Access
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
Cell·2020· 149 citedOpen Access
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling
Cell Reports·2020· 161 citedOpen Access
Activity of caspase-8 determines plasticity between cell death pathways
Nature·2019· 361 cited
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Frequent Co-authors

Vishva M. Dixit(19), Kim Newton(17), Joshua D. Webster(16), Zora Modrušan(11), Merone Roose‐Girma(10), Debra L. Dugger(7), Nobuhiko Kayagaki(6), Allie Maltzman(6), Benjamin Haley(6), Sarah Kummerfeld(6), Vinesh Vinayachandran(6), B. Franklin Pugh(6), Meredith Sagolla(4), Katherine E. Wickliffe(4), Yuxin Liang(4), Christopher M. Rose(4), Donald S. Kirkpatrick(4), Opher S. Kornfeld(3), Bettina L. Lee(3), Irma B. Stowe(3)