Nobuhiko Kayagaki

Biochemistry, Genetics and Molecular Biology · Life Sciences

63h-index26.1kcitations134works91.72yr avg
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Research Topics

Cell death mechanisms and regulation(43), Inflammasome and immune disorders(40), interferon and immune responses(24), Immune Response and Inflammation(21), NF-κB Signaling Pathways(18)

Publications134 total

Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Nature·2025Open Access
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
Nature·2025Open Access
IRF2 degradation tunes the innate immune response
2025Open Access
Ninjurin-1 Deletion Prevents Pulmonary Hypertension in the Monocrotaline Rat Model of Pulmonary Arterial Hypertension
American Journal of Respiratory and Critical Care Medicine·2025
Author Correction: Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nature Biotechnology·2025Open Access
Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis
2025· 1 citedOpen Access
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture
Nature·2024· 40 citedOpen Access
Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nature Biotechnology·2024· 47 cited
Cell death
Cell·2024· 737 citedOpen Access
Highly multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
2023· 11 citedOpen Access
Control of Cell Death in Health and Disease
Annual Review of Pathology Mechanisms of Disease·2023· 99 citedOpen Access
Epigenetic and transcriptional control of gasdermins
Seminars in Immunology·2023· 10 cited
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Nature·2023· 150 citedOpen Access
Dying cells fan the flames of inflammation
Science·2021· 271 cited
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection
Cell Host & Microbe·2021· 175 citedOpen Access
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections
Cell Reports·2021· 28 citedOpen Access
Selective activation of PFKL suppresses the phagocytic oxidative burst
Cell·2021· 150 citedOpen Access
Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function
Proceedings of the National Academy of Sciences·2021· 17 citedOpen Access
NINJ1 mediates plasma membrane rupture during lytic cell death
Nature·2021· 738 cited
Evolutionary loss of inflammasomes in carnivores to facilitate carriage of zoonotic infections
2020· 3 citedOpen Access
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Frequent Co-authors

Hideo Yagita∥(21), Vishva M. Dixit(19), Ko Okumura(16), Kim Newton(9), Irma B. Stowe(8), Bettina L. Lee(7), Noriko Yamaguchi(7), Merone Roose‐Girma(6), Wyne P. Lee(6), Kazuyoshi Takeda(6), Karen O’Rourke(5), M. NAKAYAMA(5), Søren Warming(4), Benjamin Haley(4), Juan Zhang(4), Opher S. Kornfeld(4), Joshua D. Webster(4), Denise M. Monack(4), Hiroko Tsutsui(4), Haruki Okamura(4)