Allen E. Krouse

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.4kcitations71works5.52yr avg
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Research Topics

Virus-based gene therapy research(47), RNA Interference and Gene Delivery(23), CRISPR and Genetic Engineering(20), Hematopoietic Stem Cell Transplantation(19), CAR-T cell therapy research(16)

Publications71 total

cMPL-based purification and depletion of human hematopoietic stem cells: implications for pretransplant conditioning
Blood·2025· 1 cited
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate
Cell stem cell·2024· 14 cited
CD117 Antibody Conditioning and Multiplex Base Editing Enable Rapid and Robust Fetal Hemoglobin Reactivation in a Rhesus Autologous Transplantation Model
Blood·2024· 5 cited
cMPL-Based Purification and Depletion of Human Hematopoietic Stem Cells: Implications for Pre-Transplant Conditioning
2024· 2 citedOpen Access
CD117 Antibody-Drug Conjugate Conditioning Allows Efficient Engraftment of Gene-Modified CD34+ Cells with Fertility Preservation in a Rhesus Gene Therapy Model
Blood·2023· 1 cited
Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
Nature Communications·2023· 39 citedOpen Access
Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
Molecular Therapy — Methods & Clinical Development·2023· 7 citedOpen Access
Forced enhancer-promoter rewiring to alter gene expression in animal models
Molecular Therapy — Nucleic Acids·2023· 9 citedOpen Access
Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques
Molecular Therapy — Methods & Clinical Development·2022· 9 citedOpen Access
CD117 Antibody Drug Conjugate-Based Conditioning Enables Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model
Transplantation and Cellular Therapy·2022
CD117 Antibody Drug Conjugate-Based Conditioning Allows for Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model
Blood·2021· 4 cited
Sustained fetal hemoglobin induction in vivo is achieved by <i>BCL11A</i> interference and coexpressed truncated erythropoietin receptor
Science Translational Medicine·2021· 14 cited
Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
Cell Reports Medicine·2021· 27 citedOpen Access
Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells
Molecular Therapy — Methods & Clinical Development·2021· 1 citedOpen Access
Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model
Blood Advances·2020· 7 citedOpen Access
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity
Journal of Clinical Investigation·2020· 66 citedOpen Access
A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates
Biology of Blood and Marrow Transplantation·2020· 2 citedOpen Access
Preclinical Evaluation for Engraftment of Gene-Edited CD34+ Cells with a Sickle Cell Disease Mutation in a Rhesus Transplantation Model
Blood·2019· 2 cited
Truncated Erythropoietin Receptors Confer an In Vivo Selective Advantage in Gene-Modified Erythroid Cells Expressing Fetal Hemoglobin Due to BCL11A Interference
Blood·2019· 5 cited
A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates
Blood·2019· 17 cited
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Frequent Co-authors

Robert E. Donahue(48), Aylin Bonifacino(35), John F. Tisdale(34), Mark E. Metzger(29), Naoya Uchida(29), Cynthia E. Dunbar(20), Nathaniel S. Linde(16), Selami Demirci(14), Matthew M. Hsieh(12), Jackson Gamer(8), Morgan Yapundich(8), Claire Drysdale(8), Juan J. Haro‐Mora(8), Tina Nassehi(8), Harry L. Malech(6), Chuanfeng Wu(6), So Gun Hong(6), André Larochelle(5), Theresa Engels(5), Alexis Leonard(5)