Mark E. Metzger

National Heart Lung and Blood Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index4.6kcitations123works0.02yr avg
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Research Topics

Virus-based gene therapy research(77), RNA Interference and Gene Delivery(40), Hematopoietic Stem Cell Transplantation(30), CRISPR and Genetic Engineering(23), CAR-T cell therapy research(22)

Publications123 total

CD3-immunotoxin mediated depletion of T cells in lymphoid tissues of rhesus macaques
Heliyon·2023· 1 citedOpen Access
Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells
Molecular Therapy — Methods & Clinical Development·2021· 1 citedOpen Access
Pterional Orbit Decompression in Grave Disease with Dysthyroid Optic Neuropathy
World Neurosurgery·2021· 6 cited
Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model
Blood Advances·2020· 7 citedOpen Access
NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease
Blood Advances·2020· 4 citedOpen Access
Clonal tracking of erythropoiesis in rhesus macaques
Haematologica·2019· 23 citedOpen Access
Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders
Nature Communications·2019· 30 citedOpen Access
Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque
Molecular Therapy·2019· 44 citedOpen Access
Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque
2019· 1 citedOpen Access
Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation
Blood·2018
Long-Term, Clonal Tracking Comparing Autologous Transplantation of G-CSF/SCF-Primed Bone Marrow CD34+ Cells with G-CSF/SCF-Mobilized Peripheral Blood CD34+ Cells in Rhesus Macaques
Blood·2018
Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
Molecular Therapy — Methods & Clinical Development·2018· 12 citedOpen Access
The impact of aging on primate hematopoiesis as interrogated by clonal tracking
Blood·2018· 47 citedOpen Access
Aberrant Clonal Hematopoiesis of the Erythroid and Myeloid Lineages in a Lentivirally Barcoded Rhesus Macaque
Blood·2017· 1 cited
Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients
Human Gene Therapy Clinical Development·2017· 33 citedOpen Access
Caloric Loss Associated with Apheresis
Blood·2016
Development of a New Generation, Forward-Oriented Therapeutic Vector for Hemoglobin Disorders
Blood·2016· 3 cited
Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells
Journal of Biomedical Nanotechnology·2016· 19 cited
Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model
Molecular Therapy — Methods & Clinical Development·2016· 13 citedOpen Access
Clonal Tracking of the Geographic Distribution of Hematopoiesis in Nonhuman Primates Provides New Insights into HSPC Migration and Differentiation
Blood·2015
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Frequent Co-authors

Robert E. Donahue(47), Cynthia E. Dunbar(25), John F. Tisdale(16), Aylin Bonifacino(15), Allen E. Krouse(15), Brian Agricola(13), Stephanie Sellers(9), Naoya Uchida(8), Matthew M. Hsieh(7), Irvin S. Y. Chen(6), Dong Sung An(5), Chuanfeng Wu(4), Peiman Hematti(4), Derek A. Persons(4), Jay N. Lozier(4), Richard A. Morgan(4), Brian P. Sorrentino(4), Yutaka Hanazono(3), Rong Lu(3), Robert P. Wersto(3)