Derek A. Persons

St. Jude Children's Research Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index5.9kcitations92works0.02yr avg
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Research Topics

Virus-based gene therapy research(56), CRISPR and Genetic Engineering(32), RNA Interference and Gene Delivery(25), Hemoglobinopathies and Related Disorders(22), CAR-T cell therapy research(11)

Publications92 total

Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia
Molecular Therapy·2017· 6 citedOpen Access
Data in support of transcriptional regulation and function of Fas-antisense long noncoding RNA during human erythropoiesis
Data in Brief·2016· 5 citedOpen Access
Fas-antisense long noncoding RNA is differentially expressed during maturation of human erythrocytes and confers resistance to Fas-mediated cell death
Blood Cells Molecules and Diseases·2016· 22 cited
Long noncoding RNA Saf and splicing factor 45 increase soluble Fas and resistance to apoptosis
Oncotarget·2016· 72 citedOpen Access
Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD
PLoS ONE·2016· 6 citedOpen Access
Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice
Experimental Hematology·2015· 50 citedOpen Access
Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells
Experimental Hematology·2015· 34 citedOpen Access
Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells
Molecular Therapy — Methods & Clinical Development·2015· 18 citedOpen Access
High-titer foamy virus vector transduction and integration sites of human CD34+ cell–derived SCID-repopulating cells
Molecular Therapy — Methods & Clinical Development·2014· 16 citedOpen Access
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival
Blood·2013· 57 citedOpen Access
MURINE PGK PROMOTER IN A LENTIVIRAL VECTOR IN CANINE LEUKOCYTE ADHESION DEFICIENCY AND IN HUMAN LAD-1 CD34<sup>+</sup>CELLS IN NSG MICE
Gene Therapy and Regulation·2012
GATA2 Transcription Factor Mediates Myeloid Expansion Coupled with Lymphoid Block by Transcriptional Regulation of Key Target Genes.
Blood·2012
Development of Gene Therapy for Thalassemia
Cold Spring Harbor Perspectives in Medicine·2012· 37 citedOpen Access
High-efficiency Transduction of Rhesus Hematopoietic Repopulating Cells by a Modified HIV1-based Lentiviral Vector
Molecular Therapy·2012· 36 citedOpen Access
Cell Membrane–associated Heparan Sulfate Is a Receptor for Prototype Foamy Virus in Human, Monkey, and Rodent Cells
Molecular Therapy·2012· 52 citedOpen Access
Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin
Blood·2011· 29 citedOpen Access
High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector
Blood·2011
Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX
Clinical Immunology·2011· 33 citedOpen Access
Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities
Blood·2011· 211 cited
Solving the Problem of γ-Retroviral Vectors Containing Long Terminal Repeats
Molecular Therapy·2011· 32 citedOpen Access
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Frequent Co-authors

Arthur W. Nienhuis(20), Phillip W. Hargrove(12), Hideki Hanawa(9), James A. Allay(7), Robert E. Donahue(7), Esther R. Allay(6), Brian P. Sorrentino(6), Janice M. Riberdy(6), Tamara I. Pestina(6), Cynthia E. Dunbar(5), Andrew Wilber(5), John T. Gray(5), Mark E. Metzger(4), Peiman Hematti(3), Tyra G. Wolfsberg(3), Richard A. Ashmun(3), Patrick Kelly(3), Elio F. Vanin(3), Edwin M. Horwitz(3), Steven Kepes(3)