James A. Allay

St. Jude Children's Research Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index5.1kcitations26works0.02yr avg
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Research Topics

Virus-based gene therapy research(20), Viral Infectious Diseases and Gene Expression in Insects(7), RNA Interference and Gene Delivery(6), CAR-T cell therapy research(6), CRISPR and Genetic Engineering(5)

Publications26 total

Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B
New England Journal of Medicine·2014· 1.2k citedOpen Access
Stable Factor IX Activity Following AAV-Mediated Gene Transfer in Patients with Severe Hemophilia B
Blood·2012· 3 cited
Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
New England Journal of Medicine·2011· 1.8k citedOpen Access
Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B
Blood·2011· 8 cited
Good Manufacturing Practice Production of Self-Complementary Serotype 8 Adeno-Associated Viral Vector for a Hemophilia B Clinical Trial
Human Gene Therapy·2011· 145 citedOpen Access
Long-term Safety and Efficacy Following Systemic Administration of a Self-complementary AAV Vector Encoding Human FIX Pseudotyped With Serotype 5 and 8 Capsid Proteins
Molecular Therapy·2011· 343 citedOpen Access
Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B
Blood·2010· 23 cited
Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells
Stem Cells·2009· 27 citedOpen Access
Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors
Blood·2003· 48 cited
Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells
Blood·2002· 74 citedOpen Access
Transrectal gene therapy of the prostate in the canine model
Cancer Gene Therapy·2002· 4 cited
Adenovirus p16 gene therapy for prostate cancer
World Journal of Urology·2000· 36 cited
Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells
Blood·2000· 3 cited
Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells
Blood·2000· 14 cited
High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34+ cells
Blood·2000· 48 cited
High-Efficiency Transduction and Long-Term Gene Expression with a Murine Stem Cell Retroviral Vector Encoding the Green Fluorescent Protein in Human Marrow Stromal Cells
Human Gene Therapy·1999· 115 cited
Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis
Blood·1999· 24 cited
Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis
Blood·1999· 234 cited
In vivo selection of retrovirally transduced hematopoietic stem cells
Nature Medicine·1998· 207 cited
Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells
Nature Medicine·1998· 105 cited
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Frequent Co-authors

Arthur W. Nienhuis(13), Brian P. Sorrentino(9), Derek A. Persons(8), John T. Gray(7), Amit C. Nathwani(6), Cecilia Rosales(6), Susan Sleep(6), Katherine A. High(6), Edward G. D. Tuddenham(5), Jenny McIntosh(5), Anne Riddell(5), Catherine Y. Ng(5), Mark A. Kay(5), John M. Cunningham(5), Federico Mingozzi(5), Andrew M. Davidoff(5), Savita Rangarajan(4), Pratima Chowdary(4), Bertil Glader(4), Pradip K. Rustagi(4)