Jenny McIntosh

Cancer Institute (WIA) — India

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index6.1kcitations74works5.82yr avg
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Research Topics

Virus-based gene therapy research(45), CRISPR and Genetic Engineering(16), Viral Infectious Diseases and Gene Expression in Insects(15), CAR-T cell therapy research(11), Hemophilia Treatment and Research(10)

Publications74 total

Adeno-associated viral integration profiles in human liver biopsies following Hemophilia A gene therapy
Blood·2025Open Access
Decoding Transgene Silencing from Stably Maintained AAV Genomes in Human Liver: Epigenetic Insights to Guide Next-Generation Vector Design
Blood·2025
Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody
Blood·2025· 3 cited
Sustained Clinical Benefit of AAV Gene Therapy in Severe Hemophilia B
New England Journal of Medicine·2025· 26 citedOpen Access
Reviewer #2 (Public Review): Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes
2024Open Access
Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome
Science Translational Medicine·2023· 54 citedOpen Access
Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy
Journal of Thrombosis and Haemostasis·2023· 12 citedOpen Access
BV6, AN ANTAGONIST OF INHIBITOR OF APOPTOSIS PROTEINS, SENSITIZES RESISTANT MANTLE CELL LYMPHOMA CELLS TO VENETOCLAX
Hematological Oncology·2023· 1 citedOpen Access
Preclinical evaluation of FLT190, a liver-directed AAV gene therapy for Fabry disease
Gene Therapy·2023· 36 citedOpen Access
Liver Gene Therapy
Human Gene Therapy·2022· 26 cited
The use of a transient transfected expression system to deliver high quality bispecific T-cell engager drug product, NVG-111, to the clinic for a fraction of the cost and time associated with the development and use of a producer cell line.
Journal of Clinical Oncology·2022
Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset (<i>Callithrix jacchus</i>) to evaluate gastrointestinal diseases
Journal of Medical Primatology·2022· 2 citedOpen Access
Liver-Directed AAV Gene Therapy for Gaucher Disease
Blood·2019· 5 cited
Design and Characterization of FLT210, a Potent Next Generation AAV-hFVIII Vector Candidate
Blood·2019
Liver-directed gene therapy corrects Fabry disease in mice
Molecular Genetics and Metabolism·2019· 8 cited
Liver directed AAV gene therapy to treat Gaucher disease
Molecular Genetics and Metabolism·2019· 1 cited
Potential limits of AAV‐based gene therapy with the use of new transgenes expressing factor IX fusion proteins
Haemophilia·2018· 4 cited
Therapeutic expression of human clotting factors IX and × following adeno‐associated viral vector‐mediated intrauterine gene transfer in early‐gestation fetal macaques
The FASEB Journal·2018· 31 citedOpen Access
Efficacy Evaluation of Liver-Directed Gene Therapy in Fabry Mice
Blood·2018· 6 cited
Enhancing FVIII Expression By Modifying B-Domain Sequence for Hemophilia A Gene Therapy
Blood·2018
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Frequent Co-authors

Amit C. Nathwani(28), Andrew M. Davidoff(17), Edward G. D. Tuddenham(14), Cecilia Rosales(12), Amit Nathwani(11), Simon N. Waddington(11), John T. Gray(10), Catherine Y. Ng(9), Anne Riddell(8), Pratima Chowdary(7), Ulrike M. Reiss(7), Arthur W. Nienhuis(7), Yunyu Spence(6), Christopher L. Morton(6), Katherine A. High(6), Rose Sheridan(6), Romuald Corbau(6), James A. Allay(5), Federico Mingozzi(5), Junfang Zhou(5)