Phillip W. Hargrove

University of Tennessee Health Science Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.4kcitations30works0.02yr avg
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Research Topics

Virus-based gene therapy research(19), Hemoglobinopathies and Related Disorders(12), CRISPR and Genetic Engineering(10), RNA Interference and Gene Delivery(9), Prenatal Screening and Diagnostics(8)

Publications30 total

Behavioral and molecular effects of Ubtf knockout and knockdown in mice
Brain Research·2022· 14 citedOpen Access
FOXO3 Regulates Mitochondrial Content In Maturing Red Blood Cells via Autophagy-Dependent and Independent Pathways
Experimental Hematology·2018
530. Lentiviral Vector Particles Pseudotyped with Wild-Type Baboon Endogenous Retrovirus (BAEV) Glycoprotein Outperform VSV-G Particles in Transducing Human CD34+ Cells Isolated from Cytokine-Mobilized Peripheral Blood or Bone Marrow
Molecular Therapy·2016· 2 citedOpen Access
Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells
Experimental Hematology·2015· 34 citedOpen Access
Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells
Molecular Therapy — Methods & Clinical Development·2015· 18 citedOpen Access
High-efficiency Transduction of Rhesus Hematopoietic Repopulating Cells by a Modified HIV1-based Lentiviral Vector
Molecular Therapy·2012· 36 citedOpen Access
High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector
Blood·2011
Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer
Blood·2010· 97 citedOpen Access
Transduction of Human Primitive Repopulating Hematopoietic Cells With Lentiviral Vectors Pseudotyped With Various Envelope Proteins
Molecular Therapy·2010· 19 citedOpen Access
A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts
Blood·2010· 81 citedOpen Access
High Levels of Multilineage Hematopoietic Cell Gene Marking Following Lentiviral Vector Transduction and Transplantation of Steady-State Bone Marrow CD34+ cells in a Non-Human Primate Model.
Blood·2009
A Zinc-Finger Transcriptional Activator Designed to Interact with the Gamma-Globin Gene Promoters Enhances Fetal Hemoglobin Production in Erythroid Cells Derived From Normal and Beta-Thalassemic CD34+ Cells.
Blood·2009
A Modified HIV1-Based Lentiviral Vector Can Transduce Rhesus Hematopoietic Repopulating Cells as Efficiently as An SIV Vector in An Autologous Transplantation Model.
Blood·2009
Lentiviral Vector-Mediated Transfer of the Gamma-Globin Gene Into Normal and Beta-Thalassemic Human CD34+ Cells Results in Potentially Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny.
Blood·2009
Amelioration of murine β-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both γ-globin and the MGMT drug-resistance gene
Blood·2009· 43 citedOpen Access
Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin
Molecular Therapy·2008· 101 citedOpen Access
Evaluation of a γ-Globin Lentiviral Vector in Sickle Cell Mice and Pigtail Macaques
Blood·2008· 4 cited
Gamma-globin lentiviral vector-mediated stem cell gene therapy of beta-thalassemia and sickle cell disease
Blood Cells Molecules and Diseases·2008
Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells
Molecular Therapy·2008· 110 citedOpen Access
Use of a Lentiviral Vector Encoding γ-Globin and the MGMT Drug Resistance Gene Coupled with In Vivo Drug Selection To Cure β-Thalassemia.
Blood·2007
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Frequent Co-authors

Derek A. Persons(20), Arthur W. Nienhuis(15), Hideki Hanawa(6), Tamara I. Pestina(6), Andrew Wilber(6), Yoon‐Sang Kim(6), Elio F. Vanin(5), John T. Gray(5), Steven Kepes(4), Huifen Zhao(4), Naoya Uchida(3), Coen J. Lap(3), Aylin Bonifacino(3), Allen E. Krouse(3), Mark E. Metzger(3), Matthew M. Hsieh(3), Robert E. Donahue(3), John F. Tisdale(3), Derek Persons(3), Patrick Kelly(2)