Irvin S. Y. Chen

University of California, Los Angeles — United States

Immunology and Microbiology · Life Sciences

65h-index18.4kcitations227works8.62yr avg
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Research Topics

HIV Research and Treatment(80), Virus-based gene therapy research(67), RNA Interference and Gene Delivery(60), T-cell and Retrovirus Studies(43), Animal Disease Management and Epidemiology(34)

Publications227 total

Excision of HIV-1 Provirus in Human Primary Cells with Nanocapsuled TALEN Proteins
ACS Applied Bio Materials·2025· 3 citedOpen Access
A Multi‐Enzyme Nanocascade to Target Disease‐Relevant Metabolites
Small·2024· 1 citedOpen Access
Molecular Biology and Pathogenesis of HTLV-II
2024· 1 cited
Microstructure development of calcium carbonate cement through polymorphic transformations
Cement and Concrete Composites·2024· 37 citedOpen Access
Microstructure Development of Calcium Carbonate Cement Through Polymorphic Transformations
SSRN Electronic Journal·2024· 1 citedOpen Access
Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy
Science Translational Medicine·2023· 94 citedOpen Access
CD3-immunotoxin mediated depletion of T cells in lymphoid tissues of rhesus macaques
Heliyon·2023· 1 citedOpen Access
Concrete compositions and methods
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023Open Access
Methods and compositions using calcium carbonate
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023· 1 citedOpen Access
Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages
Frontiers in Immunology·2022· 22 citedOpen Access
Efficient derivation of chimeric-antigen receptor-modified TSCM cells
Frontiers in Immunology·2022· 18 citedOpen Access
Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias
Stem Cell Research & Therapy·2021· 2 citedOpen Access
Correction: Robust CAR-T memory formation and function via hematopoietic stem cell delivery
PLoS Pathogens·2021· 7 citedOpen Access
Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques
PLoS Pathogens·2021· 12 citedOpen Access
Robust CAR-T memory formation and function via hematopoietic stem cell delivery
PLoS Pathogens·2021· 38 citedOpen Access
Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model
Journal for ImmunoTherapy of Cancer·2021· 7 citedOpen Access
Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques
JCI Insight·2021· 40 citedOpen Access
Additional file 1 of Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias
Figshare·2021Open Access
Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias
2020Open Access
The clonal repopulation of HSPC gene modified with anti–HIV-1 RNAi is not affected by preexisting HIV-1 infection
Science Advances·2020· 10 citedOpen Access
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Frequent Co-authors

Jerome A. Zack(9), Dong Sung An(8), Kouki Morizono(6), Jing Wen(6), Sheila A. Stewart(5), David W. Golde(5), Joseph D. Rosenblatt(5), Betty Poon(5), Masakazu Kamata(5), Duo Xu(5), Yoshio Koyanagi(4), Judith C. Gasson(4), Yiming Xie(4), Mark E. Metzger(4), Robert E. Donahue(4), Otto O. Yang(4), Di Wu(4), Meng Qin(4), Chaoyong Liu(4), Harry V. Vinters(3)