Krishna K. Machavaram

Simcyp (United Kingdom) — United Kingdom

Immunology and Microbiology · Life Sciences

7h-index350citations9works0.02yr avg
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Research Topics

Biosimilars and Bioanalytical Methods(4), Pharmacogenetics and Drug Metabolism(3), Monoclonal and Polyclonal Antibodies Research(3), Drug Transport and Resistance Mechanisms(2), Receptor Mechanisms and Signaling(2)

Publications9 total

Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations
The AAPS Journal·2019· 25 cited
Chapter 9. Mechanistic Modelling to Predict Transporter-mediated Drug Disposition and Drug–Drug Interactions
2016
Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics
Clinical Pharmacokinetics·2016· 81 cited
Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model
Frontiers in Immunology·2015· 35 citedOpen Access
The Modulating Effects of Endogenous Substances on Drug Metabolising Enzymes and Implications for Inter-Individual Variability and Quantitative Prediction
Current Drug Metabolism·2014· 9 cited
A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6
Clinical Pharmacology & Therapeutics·2013· 107 cited
Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model
Drug Metabolism and Disposition·2007· 67 cited
Effect of Ketoconazole and Rifampicin on the Pharmacokinetics of Ranitidine in Healthy Human Volunteers: A Possible Role of P-Glycoprotein
Drug metabolism and drug interactions·2006· 26 cited
Lymphatic absorption of subcutaneously administered proteins in sheep: Influence of different injection sites
KU ScholarWorks (The University of Kansas)·2006Open Access

Frequent Co-authors

Amin Rostami‐Hodjegan(3), Masoud Jamei(2), Katherine L. Gill(2), Rachel H. Rose(2), Manoranjenni Chetty(2), Jagannath Kota(2), Danielle N McLennan(2), Christopher J. H. Porter(2), Susan A. Charman(2), Iain Gardner(2), Lisa M. Almond(1), I. Gardner(1), Suzanne Tay(1), Susan Wong(1), Amita Joshi(1), Jane R. Kenny(1), Glenn A. Edwards(1), Linzhong Li(1), Jayasagar Gundu(1), Madhusudan Rao Yamsani(1)