Iain Gardner

Ceres — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

35h-index5.0kcitations142works2.32yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(44), Drug Transport and Resistance Mechanisms(23), Monoclonal and Polyclonal Antibodies Research(15), Drug-Induced Hepatotoxicity and Protection(13), Computational Drug Discovery Methods(11)

Publications142 total

Modeling and Simulation Identifies Endocytosis Uptake Rate and Fraction Unbound as Important Predictors of Oligonucleotide Pharmacokinetics
CPT Pharmacometrics & Systems Pharmacology·2025· 1 citedOpen Access
Testing Strategies for Metabolite-Mediated Neurotoxicity
International Journal of Molecular Sciences·2025Open Access
Correction: Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics
Journal of Pharmacokinetics and Pharmacodynamics·2025Open Access
Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations
CPT Pharmacometrics & Systems Pharmacology·2025Open Access
Mechanistic Insights into Cytokine Antagonist-Drug Interactions: A Physiologically Based Pharmacokinetic Modelling Approach with Tocilizumab as a Case Study
Pharmaceutics·2025· 1 citedOpen Access
Dietary Carnosine Supplementation in Healthy Human Volunteers: A Safety, Tolerability, Plasma and Brain Concentration Study
Nutrients·2025Open Access
The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
Environmental Toxicology and Pharmacology·2025· 1 citedOpen Access
Physiologically based pharmacokinetic modeling of aldehyde oxidase drug-drug interactions mediated by erlotinib
Drug Metabolism and Disposition·2025
Accelerating Biologics PBPK Modelling with Automated Model Building: A Tutorial
Pharmaceutics·2025· 2 citedOpen Access
The physiological limits of bispecific monoclonal antibody tissue targeting specificity
mAbs·2025· 9 citedOpen Access
Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled <scp>TMEM16A</scp> Potentiator <scp>GDC</scp>‐6988
CPT Pharmacometrics & Systems Pharmacology·2025· 1 citedOpen Access
Human jejunal enteroids for studies of epithelial drug transport and metabolism
2025Open Access
Application of a Physiologically Based Pharmacokinetic Approach to Predict Tenofovir Pharmacokinetics During Pregnancy
The AAPS Journal·2025· 1 cited
<scp>PBPK</scp>‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population
CPT Pharmacometrics & Systems Pharmacology·2025· 3 citedOpen Access
Development of a PBPK Model for Lamotrigine which Incorporates Metabolism by UGT2B10: Impact of UGT2B10 Poor Metabolizer Phenotype and Pregnancy
The AAPS Journal·2025· 3 cited
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models
Toxicology in Vitro·2025· 1 citedOpen Access
Cytokine Dynamics in Action: A Mechanistic Approach to Assess Interleukin 6 Related Therapeutic Protein‐Drug–Disease Interactions
Clinical Pharmacology & Therapeutics·2025· 2 cited
Improved identification of human hepatotoxic potential by summary variables of gene expression
ALTEX·2025· 2 citedOpen Access
An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process
ALTEX·2025· 3 citedOpen Access
Response to “Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models”
Toxicological Sciences·2024Open Access
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Frequent Co-authors

Masoud Jamei(10), Marcel Leist(9), Rosemarie Marchan(5), Susanne Hougaard Bennekou(5), Anna Forsby(5), Cristina Cadenas(5), Bob van de Water(5), Jan G. Hengstler(5), Hannah M. Jones(5), Gerhard F. Ecker(4), Paul Jennings(4), Wiebke Albrecht(4), Karolina Edlund(4), Jörg Rahnenführer(4), Martin Howard(4), Paul Walker(4), Ahmed Ghallab(3), Patrício Godoy(3), Frédéric Y. Bois(3), Albert Braeuning(3)