Iain Cumming

AstraZeneca (Netherlands) — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index540citations19works9.02yr avg
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Research Topics

Bone Metabolism and Diseases(5), Protease and Inhibitor Mechanisms(4), Receptor Mechanisms and Signaling(4), Neuroscience and Neuropharmacology Research(3), Molecular Sensors and Ion Detection(3)

Publications19 total

Generation of a potent & selective series of IRAK4 inhibitors based on a structure based, hybridization approach
Bioorganic & Medicinal Chemistry·2025
Discovery and <i>In Vivo</i> Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity
Journal of Medicinal Chemistry·2024· 18 citedOpen Access
Abstract 3088: Identification of a novel series of MTAP-selective PRMT5 inhibitors, and first disclosure of AZ-PRMT5i-1
Cancer Research·2023· 3 cited
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS<sup>G12C</sup>
Journal of Medicinal Chemistry·2022· 56 citedOpen Access
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors
Bioorganic & Medicinal Chemistry·2022· 5 citedOpen Access
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors
Bioorganic & Medicinal Chemistry·2020· 10 citedOpen Access
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS<sup>G12C</sup>
Journal of Medicinal Chemistry·2020· 80 citedOpen Access
Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines
Journal of Medicinal Chemistry·2018· 86 citedOpen Access
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3
Journal of Medicinal Chemistry·2015· 92 citedOpen Access
Human PFKFB3 in complex with an indole inhibitor 2
2015
Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization
Bioorganic & Medicinal Chemistry Letters·2010· 27 citedOpen Access
A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies
Bioorganic & Medicinal Chemistry Letters·2010· 36 citedOpen Access
Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
2010
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 17 citedOpen Access
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Dioxo-triazines as a novel series of cathepsin K inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 26 citedOpen Access
Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
MedChemComm·2010· 36 cited

Frequent Co-authors

Zoran Ranković(8), Sébastien L. Degorce(6), Graeme R. Robb(6), Jonathan Gillespie(6), James S. Scott(5), Jiaqiang Cai(5), Xavier Fradera(5), Maureen Dempster(5), Joost C.M. Uitdehaag(5), Mario van Zeeland(5), J.E. Debreczeni(4), Sam D. Groombridge(4), Jason G. Kettle(4), Hilary Lewis(4), Craig Jamieson(4), Elizabeth M. Moir(4), Ashvin Mistry(4), Paul Westwood(4), Ann Mitchell(4), Clive Long(4)