Paul Westwood

Roche (Switzerland) — Switzerland

Neuroscience · Life Sciences

11h-index729citations17works4.32yr avg
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Research Topics

Neurotransmitter Receptor Influence on Behavior(4), Protease and Inhibitor Mechanisms(4), Bone Metabolism and Diseases(4), Cannabis and Cannabinoid Research(3), Cell Adhesion Molecules Research(3)

Publications17 total

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses
npj Drug Discovery.·2025· 3 citedOpen Access
SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses
2025· 3 citedOpen Access
Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy
Journal of Medicinal Chemistry·2025· 7 cited
Discovery of Orally Available and Brain Penetrant AEP Inhibitors
Journal of Medicinal Chemistry·2023· 14 citedOpen Access
Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity
Journal of Autoimmunity·2011· 72 cited
Design, synthesis and structure–activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate
Bioorganic & Medicinal Chemistry Letters·2011· 5 citedOpen Access
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 19 citedOpen Access
1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka
Bioorganic & Medicinal Chemistry Letters·2010· 8 citedOpen Access
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 29 citedOpen Access
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 18 citedOpen Access
Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 17 citedOpen Access
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Bioorganic & Medicinal Chemistry Letters·2010· 21 citedOpen Access
Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
MedChemComm·2010· 36 cited
Allosteric Modulation of the Cannabinoid CB1 Receptor
Molecular Pharmacology·2005· 440 cited
The preclinical antidepressant-like profile of the 5-HT1A receptor agonist gepirone HCL and its metabolite, 3′-OH-gepirone
European Neuropsychopharmacology·2002· 1 cited

Frequent Co-authors

Mark Baugh(7), Emma Kinghorn(7), Maureen Dempster(7), Jiaqiang Cai(7), Clive Long(7), John Bruin(6), William Hamilton(6), Xavier Fradera(6), John Robinson(6), Zoran Ranković(5), Iain Martin(5), Joost C.M. Uitdehaag(5), Mario van Zeeland(5), Darcey Black(4), Iain Cumming(4), David Jonathan Bennett(4), Glenn Walker(3), Wilson Caulfield(3), Ashvin Mistry(3), Richard Morphy(3)