Theresa J. Roethke

GlaxoSmithKline (United States) — United States

Neuroscience · Life Sciences

16h-index1.0kcitations36works7.02yr avg
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Research Topics

Ion Channels and Receptors(8), Crystallization and Solubility Studies(8), X-ray Diffraction in Crystallography(8), Respiratory and Cough-Related Research(4), Protein Kinase Regulation and GTPase Signaling(3)

Publications36 total

Assessment of brain penetration and tumor accumulation of niraparib and olaparib: insights from multimodal imaging in preclinical models
Scientific Reports·2025· 1 citedOpen Access
Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders
Frontiers in Immunology·2024· 13 citedOpen Access
Perspective on High-Throughput Bioanalysis to Support <i>In Vitro</i> Assays in Early Drug Discovery
Bioanalysis·2023· 3 cited
Identification of a Human Whole Blood–Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo
Journal of Pharmacology and Experimental Therapeutics·2020· 2 citedOpen Access
Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions
Journal of Medicinal Chemistry·2020· 12 citedOpen Access
CCDC 1989126: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4)
Journal of Medicinal Chemistry·2019· 23 citedOpen Access
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)
ACS Medicinal Chemistry Letters·2019· 51 citedOpen Access
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model
Journal of Medicinal Chemistry·2018· 34 citedOpen Access
Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4)
Journal of Medicinal Chemistry·2018· 27 citedOpen Access
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1
ACS Medicinal Chemistry Letters·2018· 21 citedOpen Access
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress
Journal of the American Heart Association·2017· 30 citedOpen Access
Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4
ACS Medicinal Chemistry Letters·2017· 95 citedOpen Access
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase
Bioorganic & Medicinal Chemistry Letters·2013· 64 citedOpen Access
Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema
ACS Medicinal Chemistry Letters·2013· 30 citedOpen Access
An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
Science Translational Medicine·2012· 328 cited
Abstract 13510: Discovery of Orally Active Transient Receptor Potential Vanilloid 4 (TRPV4) Blockers for the Treatment of Pulmonary Edema in Heart Failure
Circulation·2011· 1 cited
Sodium and water homeostasis is maintained in rats with chronic TRPV4 blockade
The FASEB Journal·2011
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
CCDC 804986: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
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Frequent Co-authors

Robert W. Marquis(12), Karl F. Erhard(11), David J. Behm(10), Melissa H. Costell(9), Dennis A. Holt(9), Katie Ward(9), Dennis S. Yamashita(8), Thaddeus A. Tomaszek(8), Ian E. James(8), Michael W. Lark(8), Daniel F. Veber(8), Kevin S. Thorneloe(7), Krista Goodman(7), Sirishkumar D. Nidamarthy(7), Hye-Ja Oh(7), Jae Uk Jeong(7), H-Y. Cheng(7), Xiaoliu Geng(7), Priscilla Offen(7), Neysa Nevins(7)