David J. Behm

GlaxoSmithKline (United States) — United States

Medicine · Health Sciences

34h-index3.0kcitations69works4.02yr avg
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Research Topics

Cardiovascular, Neuropeptides, and Oxidative Stress Research(24), Apelin-related biomedical research(21), Ion Channels and Receptors(14), Hormonal Regulation and Hypertension(11), Cardiovascular Disease and Adiposity(10)

Publications69 total

Effect of TRPV4 Antagonist GSK2798745 on Chlorine Gas-Induced Acute Lung Injury in a Swine Model
International Journal of Molecular Sciences·2024· 4 citedOpen Access
Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury
Naunyn-Schmiedeberg s Archives of Pharmacology·2023· 4 cited
TRPV4 Specific Inhibition Ameliorates Fluid-Induced Lung Injury
SSRN Electronic Journal·2022Open Access
Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745
ACS Medicinal Chemistry Letters·2021· 20 citedOpen Access
Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough
ERJ Open Research·2021· 31 citedOpen Access
TRPV4 antagonists: a patent review (2015–2020)
Expert Opinion on Therapeutic Patents·2021· 42 cited
Identification of a Human Whole Blood–Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo
Journal of Pharmacology and Experimental Therapeutics·2020· 2 citedOpen Access
Investigating the effect of TRPV4 inhibition on pulmonary-vascular barrier permeability following segmental endotoxin challenge
Pulmonary Pharmacology & Therapeutics·2020· 14 cited
Investigating the effect of TRPV4 inhibition on pulmonary-vascular barrier permeability following segmental endotoxin challenge
2020Open Access
Targeting Pulmonary Capillary Permeability to Reduce Lung Congestion in Heart Failure: A Randomized, Controlled Pilot Trial
European Journal of Heart Failure·2020· 46 citedOpen Access
CCDC 1989126: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Recent advances in TRPV4 agonists and antagonists
Bioorganic & Medicinal Chemistry Letters·2020· 58 citedOpen Access
P115 A segmental LPS challenge study to investigate the pharmacodynamics of a TRPV4 antagonist (GSK2798745) in healthy participants
2019· 1 cited
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4)
Journal of Medicinal Chemistry·2019· 23 citedOpen Access
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)
ACS Medicinal Chemistry Letters·2019· 51 citedOpen Access
TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury
2019· 2 cited
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model
Journal of Medicinal Chemistry·2018· 34 citedOpen Access
Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4)
Journal of Medicinal Chemistry·2018· 27 citedOpen Access
Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes
Experimental Biology and Medicine·2017· 46 citedOpen Access
Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4
ACS Medicinal Chemistry Letters·2017· 95 citedOpen Access
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Frequent Co-authors

Stephen A. Douglas(20), Robert N. Willette(13), Larry J. Jolivette(8), Joseph P. Marino(7), Christopher Doe(7), Dennis A. Holt(7), Brian G. Lawhorn(7), Nambi Aiyar(7), Ross Bentley(6), Erding Hu(6), Alan R. Olzinski(6), Theresa J. Roethke(6), Melissa H. Costell(6), Weike Bao(5), Dennis Lee(5), Krista Goodman(5), Guosen Ye(5), Carl Brooks(5), Kristeen Maniscalco(5), Edward J. Brnardic(5)