Ross Bentley

Medicine · Health Sciences

23h-index1.7kcitations44works0.02yr avg
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Research Topics

Blood Coagulation and Thrombosis Mechanisms(14), Phosphodiesterase function and regulation(10), Atrial Fibrillation Management and Outcomes(8), Venous Thromboembolism Diagnosis and Management(7), Coagulation, Bradykinin, Polyphosphates, and Angioedema(6)

Publications44 total

Factor XII full and partial null in rat confers robust antithrombotic efficacy with no bleeding
Blood Coagulation & Fibrinolysis·2015· 23 cited
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
ACS Medicinal Chemistry Letters·2015· 19 citedOpen Access
Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability
Thrombosis and Haemostasis·2015· 7 cited
Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket
Bioorganic & Medicinal Chemistry Letters·2011· 8 citedOpen Access
Optimization of orally bioavailable alkyl amine renin inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 18 citedOpen Access
Differential Effects of p38 Mitogen-Activated Protein Kinase and Cyclooxygenase 2 Inhibitors in a Model of Cardiovascular Disease
Journal of Pharmacology and Experimental Therapeutics·2009· 50 cited
Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases
Journal of Medicinal Chemistry·2008· 72 citedOpen Access
SB 234551 selective ETA receptor antagonism: Perfusion/Diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection
Experimental Neurology·2008· 47 cited
Abstract 1289: Activation of the Transient Receptor Potential V4 Channel Causes Cardiovascular Collapse Mediated by Endothelial Failure
Circulation·2007
Effects of p38 MAPK Inhibitor on Angiotensin II-Dependent Hypertension, Organ Damage, and Superoxide Anion Production
Journal of Cardiovascular Pharmacology·2007· 98 cited
Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors
Journal of Medicinal Chemistry·2006· 154 citedOpen Access
Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity
Journal of Medicinal Chemistry·2006· 71 citedOpen Access
Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities
Journal of Pharmacology and Experimental Therapeutics·2006· 156 citedOpen Access
Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P<sub>1</sub>Ligand
Journal of Medicinal Chemistry·2003· 78 citedOpen Access
Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity
Bioorganic & Medicinal Chemistry Letters·2002· 52 citedOpen Access
Role of Short-Term Inhibition of Factor Xa by FXV673 in Arterial Passivation: A Study in a Chronic Model of Thrombosis in Conscious Dogs
Journal of Cardiovascular Pharmacology·2001· 12 cited
Pharmacological Characterization of a Novel Factor Xa Inhibitor, FXV673
Thrombosis Research·2001· 28 cited
Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombolysis
British Journal of Pharmacology·2001· 25 citedOpen Access
Superiority of Enoxaparin Over Heparin in Combination With a GPIIb/IIIa Receptor Antagonist During Coronary Thrombolysis in Dogs
Thrombosis Research·2001· 14 cited
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis
European Journal of Pharmacology·2000· 32 cited
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Frequent Co-authors

Robert J. Leadley(16), Valeria Chu(14), Mark H. Perrone(13), Karen Brown(12), Charles Kasiewski(12), Suzanne R. Morgan(11), Paul J. Silver(10), L T Hamel(10), Christopher T. Dunwiddie(10), Henry W. Pauls(9), Dennis Colussi(8), David J. Behm(7), Alfred P. Spada(7), Jeffrey S. Bostwick(7), Christopher Doe(6), William R. Ewing(6), Yong Mi Choi-Sledeski(5), Michael R. Becker(5), Edward D. Pagani(5), Lois L. Wright(4)