J. Kopec

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.1kcitations68works7.52yr avg
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Research Topics

Metabolism and Genetic Disorders(16), Enzyme Structure and Function(10), Folate and B Vitamins Research(7), Cancer, Hypoxia, and Metabolism(5), Amino Acid Enzymes and Metabolism(5)

Publications68 total

Real-World Applications and Experiences of AI/ML Deployment for Drug Discovery
Journal of Medicinal Chemistry·2025· 14 citedOpen Access
PIRATE: Plundering AlphaFold Predictions to Automate Protein Engineering
2024· 1 citedOpen Access
Human Galatose-1-phosphate Uridylyltransferase (GALT); A Target Enabling Package
Figshare·2019Open Access
Human Galatose-1-phosphate Uridylyltransferase (GALT), Galactokinase 1 (GALK1); A Target Enabling Package
Figshare·2019· 1 citedOpen Access
Human Galatose-1-phosphate Uridylyltransferase (GALT), Galactokinase 1 (GALK1); A Target Enabling Package
Zenodo (CERN European Organization for Nuclear Research)·2019Open Access
Human Galatose-1-phosphate Uridylyltransferase (GALT), Galactokinase 1 (GALK1); A Target Enabling Package
Zenodo (CERN European Organization for Nuclear Research)·2019Open Access
Human Galatose-1-phosphate Uridylyltransferase (GALT)
Figshare·2019Open Access
15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
Communications Biology·2019· 22 citedOpen Access
X-ray structure of human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)in complex with 15d-PGJ2
2018
X-ray structure of apo human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)
2018
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
Nature Communications·2018· 84 citedOpen Access
Crystal structure of the ACVR1 (ALK2) kinase in complex with an Quinazolinone based ALK2 inhibitor with a 4-morpholinophenyl solvent accessible group.
2018
Crystal Structure of Human Glycogenin-1 (GYG1) Tyr195pIPhe mutant, apo form
2017
Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box
2017· 1 cited
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)
2016
Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain
Scientific Reports·2016· 61 citedOpen Access
Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase
Human Molecular Genetics·2016· 51 citedOpen Access
Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase
2016
Crystal structure of human JARID1C in complex with KDM5-C49
2016
A3.03 Formation of novel citrullinated peptides by porphyromonasgingivalis pad enzyme: Implications for autoimmunity in rheumatoid arthritis
Annals of the Rheumatic Diseases·2016
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Frequent Co-authors

F. von Delft(16), C.H. Arrowsmith(16), C. Bountra(16), Wyatt W. Yue(12), N. Burgess-Brown(12), A.M. Edwards(12), Thomas J. McCorvie(8), D. Sean Froese(7), R. Chalk(7), T. Krojer(7), Fidelma Fitzpatrick(7), Fiona Fitzpatrick(6), Claire Strain‐Damerell(6), C. Tallant(6), W.W. Yue(6), D.M. Pinkas(5), Walter Keller(4), G.A. Bezerra(4), G. Schneider(4), J.A. Newman(4)