Stefan Zielonka

Merck (Germany) — Germany

Medicine · Health Sciences

25h-index1.8kcitations81works6.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(67), Protein purification and stability(25), Glycosylation and Glycoproteins Research(22), CAR-T cell therapy research(17), Viral Infectious Diseases and Gene Expression in Insects(15)

Publications81 total

Multifunctional antibody-derived IL-12 mimetics: prospects of future clinical development
Expert Opinion on Investigational Drugs·2026
From discovery to the clinic: structural insights, engineering options, clinical, and ‘next wave’ applications of camelid-derived single-domain antibodies
mAbs·2025· 3 citedOpen Access
Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface: a systematic predictive case study
mAbs·2025· 3 citedOpen Access
Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies
Frontiers in Immunology·2025· 1 citedOpen Access
Trispecific SEED antibodies engineered for neutrophil-mediated cell killing
mAbs·2025· 2 citedOpen Access
Allosteric Antibody Modulation of EGFR Activity: Bridging Experiment and In Silico Modeling
Journal of Molecular Biology·2025· 3 citedOpen Access
Taming interleukin‐12: Engineering of bispecific antibody‐based <scp>IL</scp>‐12 mimetics with biased agonism capacities
Protein Science·2025· 5 citedOpen Access
Enhancing NK cell-mediated tumor killing of B7-H6+ cells with bispecific antibodies targeting allosteric sites of NKp30
Molecular Therapy Oncology·2024· 1 citedOpen Access
On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality
Protein Science·2024· 17 citedOpen Access
Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects
Frontiers in Immunology·2024· 21 citedOpen Access
Antikörper-basierte Zytokinmimetika
BIOspektrum·2024Open Access
Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics
Expert Opinion on Biological Therapy·2024· 6 citedOpen Access
Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers
mAbs·2024· 18 citedOpen Access
Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features
Biological Chemistry·2024· 3 citedOpen Access
A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody–Drug Conjugates
International Journal of Molecular Sciences·2024· 7 citedOpen Access
Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET
mAbs·2024· 10 citedOpen Access
Development of a c-MET x CD137 bispecific antibody for targeted immune agonism in cancer immunotherapy
Cancer Treatment and Research Communications·2024· 2 citedOpen Access
Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format
Frontiers in Immunology·2023· 7 citedOpen Access
AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study
Frontiers in Molecular Biosciences·2023· 22 citedOpen Access
A library approach for the <i>de novo</i> high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization
mAbs·2023· 18 citedOpen Access
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Frequent Co-authors

Simon Krah(36), Harald Kolmar(33), Julius Grzeschik(17), Lukas Pekar(17), Stefan Becker(15), Lars Toleikis(14), Achim Doerner(12), Bernhard Valldorf(11), Christian Schröter(10), Andreas Evers(10), Doreen Könning(8), Martin Empting(8), Carolin Sellmann(8), Steffen C. Hinz(8), Paul Arras(8), Matthias Peipp(7), Katja Klausz(6), Ammelie Svea Boje(6), Desislava Yanakieva(6), Vanessa Siegmund(6)