Lars Toleikis

Merck (Germany) — Germany

Medicine · Health Sciences

21h-index1.2kcitations37works6.42yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(34), Glycosylation and Glycoproteins Research(11), Protein purification and stability(10), CAR-T cell therapy research(7), Transgenic Plants and Applications(5)

Publications37 total

Trispecific SEED antibodies engineered for neutrophil-mediated cell killing
mAbs·2025· 2 citedOpen Access
Enhancing NK cell-mediated tumor killing of B7-H6+ cells with bispecific antibodies targeting allosteric sites of NKp30
Molecular Therapy Oncology·2024· 1 citedOpen Access
A platform for the early selection of non-competitive antibody-fragments from yeast surface display libraries
Biological Chemistry·2024· 5 citedOpen Access
Discovery of potent allosteric antibodies inhibiting EGFR
mAbs·2024· 6 citedOpen Access
Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers
mAbs·2024· 18 citedOpen Access
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition
mAbs·2023· 19 citedOpen Access
One-Pot Droplet RT-OE-PCR for the Generation of Natively Paired Antibody Immune Libraries
Methods in molecular biology·2023
Facile One-Step Generation of Camelid VHH and Avian scFv Libraries for Phage Display by Golden Gate Cloning
Methods in molecular biology·2023· 1 cited
Multifunctional NK Cell–Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release
The Journal of Immunology·2022· 31 citedOpen Access
Abstract 5284: M1231 is a bispecific anti-MUC1xEGFR antibody-drug conjugate designed to treat solid tumors with MUC1 and EGFR co-expression
Cancer Research·2022· 24 cited
Efficient spontaneous site-selective cysteine-mediated toxin attachment within a structural loop of antibodies
Biochimica et Biophysica Acta (BBA) - General Subjects·2022· 3 cited
Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities
mAbs·2022· 30 citedOpen Access
Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity
Frontiers in Immunology·2021· 19 citedOpen Access
Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding
OncoImmunology·2021· 33 citedOpen Access
Affinity Maturation of B7-H6 Translates into Enhanced NK Cell–Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement
The Journal of Immunology·2020· 45 citedOpen Access
195 Avelumab internalization and lysosomal degradation by circulating immune cells in human is mediated by both Fc gamma Receptor (FcgR) and PD-L1 binding
Regular and Young Investigator Award Abstracts·2020· 2 citedOpen Access
A One-Step Process for the Construction of Phage Display scFv and VHH Libraries
Molecular Biotechnology·2020· 27 cited
Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform
mAbs·2020· 31 citedOpen Access
Intein mediated high throughput screening for bispecific antibodies
mAbs·2020· 29 citedOpen Access
Isolation of Antigen-Specific VHH Single-Domain Antibodies by Combining Animal Immunization with Yeast Surface Display
Methods in molecular biology·2019· 27 cited
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Frequent Co-authors

Harald Kolmar(19), Simon Krah(18), Stefan Zielonka(18), Stefan Becker(17), Lukas Pekar(14), Björn Hock(7), Carolin Sellmann(6), Stefan Dübel(5), Achim Doerner(5), Laura Rhiel(5), Michael Hust(4), Christian Schröter(4), Ralf Günther(4), Katja Klausz(4), Michael Busch(4), Bernhard Valldorf(4), Ammelie Svea Boje(4), Matthias Peipp(4), Desislava Yanakieva(4), André Frenzel(3)