Wilhelmus E. A. de Witte

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index682citations30works0.72yr avg
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Research Topics

Receptor Mechanisms and Signaling(11), Innovative Microfluidic and Catalytic Techniques Innovation(7), Computational Drug Discovery Methods(5), Neuroscience and Neuropharmacology Research(4), Drug Transport and Resistance Mechanisms(4)

Publications30 total

Continuous infusion simulations in PBPK and QSP models reveal steady-state properties and rate-limiting steps.
2026Open Access
From simulation to application: enhancing preclinical evaluation of dissolvable microarray patches through PBPK modelling
Drug Delivery and Translational Research·2025Open Access
Prediction of a <scp>CLDN18.2</scp> Targeted Antibody Drug Conjugate Pharmacokinetics in Cancer Patients Using <scp>PBPK</scp> Modeling and Simulation
CPT Pharmacometrics & Systems Pharmacology·2025· 1 citedOpen Access
Whole-Body Physiologically Based Pharmacokinetic Modeling Framework for Tissue Target Engagement of CD3 Bispecific Antibodies
Pharmaceutics·2025· 1 citedOpen Access
Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (<scp>OSP</scp>) Community Conference
CPT Pharmacometrics & Systems Pharmacology·2025Open Access
Local depletion of large molecule drugs due to target binding in tissue interstitial space
CPT Pharmacometrics & Systems Pharmacology·2024· 7 citedOpen Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Reproducibility Study on a PBPK Model of FcRn-Mediated Recycling for Large Molecules
Physiome·2024Open Access
Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules
Journal of Pharmacokinetics and Pharmacodynamics·2023· 8 cited
The implications of target saturation for the use of drug–target residence time
Nature Reviews Drug Discovery·2018· 34 citedOpen Access
Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
Journal of Pharmacokinetics and Pharmacodynamics·2018Open Access
<i>In vitro</i>and<i>in silico</i>analysis of the effects of<scp>D</scp><sub>2</sub>receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
British Journal of Pharmacology·2018· 15 citedOpen Access
Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
Journal of Pharmacokinetics and Pharmacodynamics·2018· 7 citedOpen Access
Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling
The AAPS Journal·2017· 19 citedOpen Access
From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action
Scientific Reports·2017· 10 citedOpen Access
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Frequent Co-authors

Elizabeth C. M. de Lange(13), Meindert Danhof(8), Lindsay B. Avery(8), Tom Van Bogaert(8), Maria Laura Sargentini‐Maier(8), Piet H. van der Graaf(7), Soroush Safaei(7), Veronique De Brabandere(7), Laura H. Heitman(4), Stephan Schaller(4), Yin Cheong Wong(3), Indira Nederpelt(3), Adriaan P. IJzerman(3), Victoria Georgi(2), Herman S. Overkleeft(2), Maria Kuzikov(2), Sheraz Gul(2), Vivi Rottschäfer(2), L. A. Peletier(2), Doris A. Schuetz(1)