Dennis A. Dougherty

California Institute of Technology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

69h-index25.5kcitations386works11.52yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(131), Receptor Mechanisms and Signaling(93), Ion channel regulation and function(75), Neuroscience and Neuropharmacology Research(36), Molecular spectroscopy and chirality(29)

Publications386 total

BPS2026 - Computational design of protein-based biosensors toward wearable measuring of nicotine concentration and dynamics
Biophysical Journal·2026
Hydrogel Encapsulation of a Designed Fluorescent Protein Biosensor for Continuous Measurements of Sub-100 nM Nicotine
ACS Applied Bio Materials·2025
Continuous Nicotine Monitors for Personal Nicotine Pharmacokinetics: A Receptor-Aware Research Agenda
Nicotine & Tobacco Research·2025· 1 cited
The Cation−π Interaction in Chemistry and Biology
Chemical Reviews·2025· 63 citedOpen Access
Hydrogel encapsulation of a designed fluorescent protein biosensor for continuous measurements of sub-100 nanomolar nicotine
2024· 1 citedOpen Access
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids
Protein Engineering Design and Selection·2024· 4 citedOpen Access
Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients
Qeios·2023Open Access
β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats
eNeuro·2023· 9 citedOpen Access
Human α6β4 Nicotinic Acetylcholine Receptor: Heterologous Expression and Agonist Behavior Provide Insights into the Immediate Binding Site
Molecular Pharmacology·2023· 4 cited
Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Journal of Neuroscience·2023· 16 citedOpen Access
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids
2023· 4 citedOpen Access
Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
eLife·2022· 3 citedOpen Access
Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues
Membranes·2022· 3 citedOpen Access
Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor
Journal of the American Chemical Society·2022· 16 cited
Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
2022· 2 citedOpen Access
5-HT<sub>3</sub> Receptor MX Helix Contributes to Receptor Function
ACS Chemical Neuroscience·2022· 3 citedOpen Access
Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids
Journal of the American Chemical Society·2022· 10 citedOpen Access
Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-methadone for Use in Cells, Organelles, and Biofluids
2022· 3 citedOpen Access
Fluorescence Screens for Identifying Central Nervous System–Acting Drug–Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics
BIO-PROTOCOL·2022· 7 citedOpen Access
Author response: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
2021Open Access
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Frequent Co-authors

Henry A. Lester(19), Sarah C. R. Lummis(6), Justin P. Gallivan(5), Darren L. Beene(5), Patrick C. Kearney(4), David A. Stauffer(3), Wenge Zhong(3), Sandro Mecozzi(3), Mark W. Nowak(3), Robert A. Kumpf(2), Yinong Zhang(2), Anthony P. West(2), Walrati Limapichat(2), Robert H. Grubbs(2), Xinan Xiu(2), A. K. McCurdy(2), Margaret E. Saks(2), Cesar Labarca(2), Scott Silverman(2), John Abelson(2)