Kate Nesbitt

Queen's University — Canada

Medicine · Health Sciences

12h-index512citations29works13.02yr avg
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Research Topics

Platelet Disorders and Treatments(13), Blood Coagulation and Thrombosis Mechanisms(11), Hemophilia Treatment and Research(11), Venous Thromboembolism Diagnosis and Management(3), Complement system in diseases(3)

Publications29 total

Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A
Science Translational Medicine·2024· 13 citedOpen Access
OC 13.1 Scavenger Receptor Stabilin-2 is a Major Regulator of VWF Propeptide Clearance
Research and Practice in Thrombosis and Haemostasis·2023Open Access
OC 44.5 A Gut Metabolite-Based Dietary Therapy Influences FVIII Inhibitor Production with Novel Relationships between the Gut Microbiota, Blood Metabolome, and Immune Cell Frequencies
Research and Practice in Thrombosis and Haemostasis·2023Open Access
The mechanistic and structural role of von Willebrand factor in endotoxemia-enhanced deep vein thrombosis in mice
Journal of Thrombosis and Haemostasis·2023· 7 citedOpen Access
Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects
Blood Advances·2022Open Access
Histones link inflammation and thrombosis through the induction of Weibel-Palade Body exocytosis
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Stabilin-2 Deficiency Enhances Venous Thrombus Size, Alters Thrombus Composition, and Increases Plasma Procoagulant Activity in Mice
Journal of Vascular Surgery·2021
Stabilin‐2 deficiency increases thrombotic burden and alters the composition of venous thrombi in a mouse model
Journal of Thrombosis and Haemostasis·2021· 15 cited
Molecular coevolution of coagulation factor VIII and von Willebrand factor
Blood Advances·2021· 7 citedOpen Access
von Willebrand Factor Is a Critical Mediator of Deep Vein Thrombosis in a Mouse Model of Diet-Induced Obesity
Arteriosclerosis Thrombosis and Vascular Biology·2020· 35 citedOpen Access
Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation
Blood·2020· 58 citedOpen Access
Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A
Blood Advances·2020· 4 citedOpen Access
The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen
Journal of Thrombosis and Haemostasis·2019· 27 citedOpen Access
Shear stress and platelet‐induced tensile forces regulate ADAMTS13‐localization within the platelet thrombus
Research and Practice in Thrombosis and Haemostasis·2019· 11 citedOpen Access
The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF‐dependent and independent manner
Journal of Thrombosis and Haemostasis·2019· 44 citedOpen Access
The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity
Journal of Clinical Investigation·2018· 76 citedOpen Access
N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice
Haematologica·2018· 26 citedOpen Access
Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms
Haematologica·2018· 9 citedOpen Access
Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice
Journal of Thrombosis and Haemostasis·2017· 19 citedOpen Access
VWF-FVIII Interactions Influence Hemostatic Thrombus Stability in Murine Models of Hemophilia Α and Type 2N VWD
Blood·2016
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Frequent Co-authors

David Lillicrap(22), Laura L. Swystun(15), Courtney Dwyer(8), Alison Michels(7), Christine Hough(7), Jesse D. Lai(5), Colleen Notley(5), Orla Rawley(5), Jeffrey Mewburn(4), Paula D. James(3), Ilinca Georgescu(3), Dominique Cartier(3), Christine Brown(3), Wilma M. Hopman(2), Cunjie Zhang(2), James W. Dennis(2), Chris Dwyer(2), C. Brown(2), Paul Kubes(2), Stephen M. Cain(2)