Christine Hough

University of Ferrara — Italy

Medicine · Health Sciences

27h-index2.0kcitations65works0.02yr avg
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Research Topics

Hemophilia Treatment and Research(40), Platelet Disorders and Treatments(29), Virus-based gene therapy research(14), Blood Coagulation and Thrombosis Mechanisms(14), Monoclonal and Polyclonal Antibodies Research(11)

Publications65 total

OC 44.5 A Gut Metabolite-Based Dietary Therapy Influences FVIII Inhibitor Production with Novel Relationships between the Gut Microbiota, Blood Metabolome, and Immune Cell Frequencies
Research and Practice in Thrombosis and Haemostasis·2023Open Access
Mice possess a more limited natural antihuman factor VIII antibody repertoire than humans that is produced disproportionately by marginal zone B cells
Journal of Thrombosis and Haemostasis·2023· 1 citedOpen Access
Heterogeneity and reciprocity of FVIII and VWF expression, and the response to shear stress in cultured human endothelial cells
Journal of Thrombosis and Haemostasis·2022· 9 citedOpen Access
Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A
Blood·2022· 38 citedOpen Access
Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A
Blood Advances·2020· 4 citedOpen Access
Recombinant Factor VIII Fc Inhibits B Cell Activation via Engagement of the FcγRIIB Receptor
Frontiers in Immunology·2020· 8 citedOpen Access
Shear stress and platelet‐induced tensile forces regulate ADAMTS13‐localization within the platelet thrombus
Research and Practice in Thrombosis and Haemostasis·2019· 11 citedOpen Access
N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice
Haematologica·2018· 26 citedOpen Access
Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms
Haematologica·2018· 9 citedOpen Access
Early cellular interactions and immune transcriptome profiles in human factor VIII‐exposed hemophilia A mice
Journal of Thrombosis and Haemostasis·2017· 22 citedOpen Access
A Factor VIII Fusion with an Inactivated FIX Generates a Biologically Active Molecule with Delayed Clearance in a FVIII/VWF Knockout Mouse Model
Blood·2017
Biological considerations of plasma-derived and recombinant factor VIII immunogenicity
Blood·2017· 48 citedOpen Access
Development of an Optimized rAAV2/6 Human Factor 8 cDNA Vector Cassette for Hemophilia a Gene Therapy
Blood·2016· 2 cited
Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model
Blood·2016· 1 cited
Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A
Blood·2016· 29 citedOpen Access
Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies
Journal of Thrombosis and Haemostasis·2016· 40 citedOpen Access
War and peace: Factor VIII and the adaptive immune response
Cellular Immunology·2015· 17 cited
To clear or to fear: An innate perspective on factor VIII immunity
Cellular Immunology·2015· 15 cited
Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII
Molecular Therapy — Methods & Clinical Development·2015· 2 citedOpen Access
Immunization Against Influenza but Not MMR Modulates the Anti-Factor VIII Immune Response in Hemophilia Α Mice
Blood·2014
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Frequent Co-authors

David Lillicrap(47), Colleen Notley(13), Carol Hegadorn(12), Andrea Labelle(8), Brian D. Brown(7), Jesse D. Lai(7), Shawn Tinlin(6), Erin Burnett(6), Margareth C. Ozelo(6), Kate Nesbitt(6), Maria T. Georgescu(6), Maha Othman(5), Cherie Cameron(5), Hideto Matsui(5), Paul Moorehead(5), Christine Brown(4), Lee A. O’Brien(4), Ergül Berber(4), Braden Waters(4), Mohammad Qadura(4)