François Lévesque

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Engineering · Physical Sciences

26h-index3.3kcitations81works7.42yr avg
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Research Topics

Innovative Microfluidic and Catalytic Techniques Innovation(26), Radical Photochemical Reactions(14), Crystallization and Solubility Studies(8), Ion-surface interactions and analysis(8), X-ray Diffraction in Crystallography(8)

Publications81 total

Application of Direct Inject Liquid Chromatography (DILC) as Real-Time Process Analytical Technology for Flow Reactions
Organic Process Research & Development·2025
Novel Application of Direct Inject Liquid Chromatography (DILCTM) as Real-time Process Analytical Technology for Flow Reactions
2025· 1 citedOpen Access
A Scalable Flow Electrolysis of Heterogeneous Mixtures Using a Rotating Cylinder Electrode Reactor: Access to a Chiral Iminophosphorane
Organic Process Research & Development·2025· 1 cited
Scalable Flow Electrosynthesis of Iminophosphoranes
Organic Process Research & Development·2025· 2 cited
“Build Your Own” ADC Mimics: Identification of Nontoxic Linker/Payload Mimics for HIC-Based DAR Determination, High-Throughput Optimization, and Continuous Flow Conjugation
Organic Process Research & Development·2024· 4 cited
Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multigram Deliveries of Peptides
Organic Process Research & Development·2024· 21 cited
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Organic Process Research & Development·2024· 1 cited
Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation
Organic Process Research & Development·2024· 34 cited
“Build your own” ADC mimics: Identification of non-toxic linker/payload mimics for HIC-based DAR determination, high-throughput optimization, and continuous flow conjugation
2024· 3 citedOpen Access
Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib
Organic Process Research & Development·2023· 13 cited
Multigram Electrochemical Hofmann Rearrangement Using a Spinning Three-Dimensional Anode
Organic Process Research & Development·2023· 26 cited
High Resolution Spatiotemporal Time Series of Water Column Structure Data Acquired with Autonomous Operated Profiling CTD Mounted on a Viking Met-Ocean Buoy in Support of Autonomous Vehicle Test Area
2023
Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis
Nature·2023· 64 citedOpen Access
Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis
2023· 4 citedOpen Access
From at-line to online NMR: coupling probe-based autosampler with benchtop NMR
Reaction Chemistry & Engineering·2023· 7 cited
Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis - NMR Spectra
Figshare·2023Open Access
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis
Organic Process Research & Development·2022· 55 cited
Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination
Organic Process Research & Development·2021· 85 cited
Benzylic Photobromination for the Synthesis of Belzutifan: Elucidation of Reaction Mechanisms Using In Situ LED-NMR
The Journal of Organic Chemistry·2021· 28 cited
CCDC 2018690: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
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Frequent Co-authors

Peter H. Seeberger(9), Jonathan P. McMullen(9), John R. Naber(8), Cecilia Bottecchia(7), Dan Lehnherr(7), Yining Ji(6), Mikhail Reibarkh(5), Michael K. Wismer(5), Alexander G. O’Brien(5), Karthik Narsimhan(5), Mark Weisel(5), Kevin M. Maloney(5), Guillaume Bélanger(5), Danielle M. Schultz(4), A. Benyagoub(4), E. Paumier(4), Daniel A. DiRocco(3), Ian W. Davies(3), Emily B. Corcoran(3), F. Couvreur(3)