Jonathan P. McMullen

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Engineering · Physical Sciences

22h-index3.2kcitations60works9.42yr avg
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Research Topics

Innovative Microfluidic and Catalytic Techniques Innovation(30), Crystallization and Solubility Studies(13), Microfluidic and Capillary Electrophoresis Applications(11), Analytical Chemistry and Chromatography(11), Process Optimization and Integration(7)

Publications60 total

A Comparative Study of Strategies for Incorporating Uncertainty in Design Space Determination for Pharmaceutical Manufacturing
Industrial & Engineering Chemistry Research·2025
Data-Driven Modeling for the Enhanced Understanding for the Crystallization of an Active Pharmaceutical Ingredient
Organic Process Research & Development·2025· 1 cited
Editorial overview: Digital design of pharmaceutical manufacturing processes
Current Opinion in Chemical Engineering·2025
Development and simulation of annular flow photoreactors: integration of light-diffusing fibers as optical diffusers with laser diodes
Reaction Chemistry & Engineering·2024· 1 citedOpen Access
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Organic Process Research & Development·2024· 1 cited
Integrating Functional Principal Component Analysis with Data-Rich Experimentation for Enhanced Drug Substance Development
Organic Process Research & Development·2024· 7 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5─Chemoenzymatic Diastereoselective Fluorination/DKR
Organic Process Research & Development·2024· 12 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6─Development of a Nucleophilic Aromatic Substitution in Water
Organic Process Research & Development·2024· 8 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy
Organic Process Research & Development·2024· 21 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 4─Applications of Process Analytical Technology in Heterogeneous Biocatalytic Hydroxylation
Organic Process Research & Development·2024· 11 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 3─Development of a Scalable Enzymatic Oxidation Process
Organic Process Research & Development·2024· 19 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 2─Development of a Scalable Nickel-Catalyzed Sulfonylation
Organic Process Research & Development·2024· 12 cited
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
Angewandte Chemie·2024· 1 cited
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
Angewandte Chemie International Edition·2024· 51 citedOpen Access
Process knowledge for drug substance production <i>via</i> kinetic modeling, parameter estimability analysis and reaction optimization
Reaction Chemistry & Engineering·2024· 2 cited
Accelerating reaction optimization through data-rich experimentation and machine-assisted process development
Reaction Chemistry & Engineering·2024· 4 citedOpen Access
Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib
Organic Process Research & Development·2023· 13 cited
Parameter estimation and estimability analysis in pharmaceutical models with uncertain inputs
AIChE Journal·2023· 10 citedOpen Access
Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib
ACS Catalysis·2023· 25 citedOpen Access
Parameter Estimation and Estimability Analysis in Pharmaceutical Models with Uncertain Inputs
2023· 1 citedOpen Access
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Frequent Co-authors

Klavs F. Jensen(10), François Lévesque(10), Brian M. Wyvratt(8), John R. Naber(7), Karthik Narsimhan(7), Daniel A. DiRocco(7), Shane T. Grosser(7), Jungchul Kim(6), Kevin M. Maloney(6), Rekha Gangam(5), Embarek Alwedi(5), David A. Thaisrivongs(5), Ryan L. Hartman(4), Yining Ji(4), Stephen M. Dalby(4), Wai Ling Cheung‐Lee(4), Joshua N. Kolev(4), Weilan Pan(4), Kotoe Abe(4), Birgit Kosjek(4)