Shane T. Grosser

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Engineering · Physical Sciences

14h-index1.0kcitations29works5.92yr avg
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Research Topics

Innovative Microfluidic and Catalytic Techniques Innovation(14), Enzyme Catalysis and Immobilization(8), Analytical Chemistry and Chromatography(8), Microfluidic and Capillary Electrophoresis Applications(5), Mass Spectrometry Techniques and Applications(4)

Publications29 total

Data-Rich Monitoring and Optimization of a Complex Biocatalytic Oxidative Desymmetrization via Integrated Flow-NMR and PAT
Organic Process Research & Development·2026
Author response for "Accelerating Cross-Modality Reaction Optimization via Robotically Automated Vacuum Enabled Direct-inject Mass Spectrometry (RAVE MS)"
2025
Accelerating Cross-Modality Reaction Optimization via Robotically Automated Vacuum Enabled Direct-inject Mass Spectrometry (RAVE MS)
2025Open Access
Accelerating cross-modality reaction optimization <i>via</i> robotically automated vacuum enabled direct-inject mass spectrometry (RAVE MS)
Reaction Chemistry & Engineering·2025
Active learning enabled reactor characterization for mass transfer in aerobic oxidation reactions
Reaction Chemistry & Engineering·2024· 1 citedOpen Access
Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
Organic Process Research & Development·2024· 13 cited
Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multigram Deliveries of Peptides
Organic Process Research & Development·2024· 21 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 4─Applications of Process Analytical Technology in Heterogeneous Biocatalytic Hydroxylation
Organic Process Research & Development·2024· 11 cited
Dynamic sampling in autonomous process optimization
Chemical Science·2024· 7 citedOpen Access
Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib
Organic Process Research & Development·2023· 13 cited
Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
2023· 4 citedOpen Access
Automated End-to-End Workflow for Volumetric Mass-Transfer Coefficient (<i>k</i><sub>L</sub><i>a</i>) Characterization in Small-Molecule Pharmaceutical Development
Organic Process Research & Development·2023· 16 citedOpen Access
Vision-Guided Automation Platform for Liquid–Liquid Extraction and Workup Development
Organic Process Research & Development·2023· 19 cited
Portable capillary LC for in‐line UV monitoring and MS detection: Comparable sensitivity and much lower solvent consumption
Journal of Separation Science·2023· 4 citedOpen Access
Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib
ACS Catalysis·2023· 25 citedOpen Access
Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib
2023· 1 citedOpen Access
Data-rich process development of immobilized biocatalysts in flow
Reaction Chemistry & Engineering·2022· 7 citedOpen Access
Raman hyperspectral imaging with multivariate analysis for investigating enzyme immobilization
The Analyst·2020· 29 cited
Design of an in vitro biocatalytic cascade for the manufacture of islatravir
Science·2019· 603 cited
Stoichiometry identification of pharmaceutical reactions using the constrained dynamic response surface methodology
AIChE Journal·2019· 17 cited
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Frequent Co-authors

Jacob H. Forstater(8), Jonathan P. McMullen(7), Keith Mattern(7), Kevin M. Maloney(6), Deeptak Verma(5), Michael J. Di Maso(5), Claire M. Eberle(5), Yining Ji(4), James Schneider(4), Sarah R. Moor(4), Anna Fryszkowska(3), Oscar Alvizo(3), Margie Borra‐Garske(3), Paul N. Devine(3), Da Duan(3), Jeffrey C. Moore(3), Grant S. Murphy(3), Christopher C. Nawrat(3), Jovana Nazor(3), Sandra A. Robaire(3)