Keith Mattern

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Engineering · Physical Sciences

6h-index210citations18works9.12yr avg
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Research Topics

Innovative Microfluidic and Catalytic Techniques Innovation(5), Enzyme Catalysis and Immobilization(4), Biochemical and Molecular Research(4), Analytical Chemistry and Chromatography(3), Microbial Metabolic Engineering and Bioproduction(3)

Publications18 total

Data-Rich Monitoring and Optimization of a Complex Biocatalytic Oxidative Desymmetrization via Integrated Flow-NMR and PAT
Organic Process Research & Development·2026
Biocatalytic Aerobic Oxidation for Large-Scale Production of <i>trans</i>-3-Hydroxy-<scp>l</scp>-Proline
Organic Process Research & Development·2025· 2 cited
Development of Flow-NMR Spectroscopy for Real-Time Monitoring and Kinetics Studies of Biomolecules: Case Study of Liraglutide Oligomerization
Analytical Chemistry·2025· 1 cited
Scalable Flow Electrosynthesis of Iminophosphoranes
Organic Process Research & Development·2025· 2 cited
Active learning enabled reactor characterization for mass transfer in aerobic oxidation reactions
Reaction Chemistry & Engineering·2024· 1 citedOpen Access
Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
Organic Process Research & Development·2024· 13 cited
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 4─Applications of Process Analytical Technology in Heterogeneous Biocatalytic Hydroxylation
Organic Process Research & Development·2024· 11 cited
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
Angewandte Chemie·2024· 1 cited
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
Angewandte Chemie International Edition·2024· 51 citedOpen Access
Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
2023· 4 citedOpen Access
Automated End-to-End Workflow for Volumetric Mass-Transfer Coefficient (<i>k</i><sub>L</sub><i>a</i>) Characterization in Small-Molecule Pharmaceutical Development
Organic Process Research & Development·2023· 16 citedOpen Access
Portable capillary LC for in‐line UV monitoring and MS detection: Comparable sensitivity and much lower solvent consumption
Journal of Separation Science·2023· 4 citedOpen Access
Electrochemical Recycling of Adenosine Triphosphate in Biocatalytic Reaction Cascades
Journal of the American Chemical Society·2022· 40 cited
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis
Organic Process Research & Development·2022· 55 cited
Electrochemical Recycling of Adenosine Triphosphate in Biocatalytic Reaction Cascades
2022· 2 citedOpen Access
Discovery and Development of an Unusual Organocatalyst for the Conversion of Thymidine to Furanoid Glycal
Organic Process Research & Development·2021· 6 cited
Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient
Organic Process Research & Development·2021· 1 cited
Passion: The Flavor of Life
Bucknell Digital Commons (Bucknell University)·2011Open Access

Frequent Co-authors

Shane T. Grosser(7), Kevin M. Maloney(6), Victoria Zhang(5), Yining Ji(4), Li Xiao(4), Zachary E. X. Dance(4), Serge Ruccolo(4), Kevin Stone(3), Neil A. Strotman(3), Joshua N. Kolev(3), Rekha Gangam(3), Kotoe Abe(3), Embarek Alwedi(3), Jungchul Kim(3), Nastaran Salehi Marzijarani(3), Jonathan P. McMullen(3), Ajit Vikram(3), Alexandra C. Sun(3), Anna Fryszkowska(3), Erica L. Schwalm(3)