Lefkothea C. Papadopoulou

Aristotle University of Thessaloniki — Greece

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index2.0kcitations38works1.52yr avg
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Research Topics

Mitochondrial Function and Pathology(14), ATP Synthase and ATPases Research(7), RNA Interference and Gene Delivery(6), Virus-based gene therapy research(5), CAR-T cell therapy research(5)

Publications37 total

Natural Nrf2 activators modulate antioxidant gene expression and apoptosis in leukemic K-562 cells
Medical Oncology·2025· 1 citedOpen Access
Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K‑562 and colorectal HCT‑116 cancer cells
International Journal of Oncology·2024· 2 citedOpen Access
Synthesis and biological evaluation of 99mTc-tricarbonyl complexes of C-3 carboxy derivatives of fluoroquinolones in infection and tumor animal models
Inorganica Chimica Acta·2023· 3 cited
Conventional and Innovative Molecular Approaches Developed for Treating Hemoglobinopathies
Elsevier eBooks·2023
Recruiting In Vitro Transcribed mRNA against Cancer Immunotherapy: A Contemporary Appraisal of the Current Landscape
Current Issues in Molecular Biology·2023· 7 citedOpen Access
Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency
Pharmaceutics·2023· 6 citedOpen Access
An Innovative PTD-IVT-mRNA Delivery Platform for CAR Immunotherapy of ErbB(+) Solid Tumor Neoplastic Cells
Biomedicines·2022· 8 citedOpen Access
In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of Twenty-First Century: Exploitation of Peptides as Carriers for Their Intracellular Delivery
RNA technologies·2022· 3 cited
Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders
Molecular Therapy — Nucleic Acids·2021· 31 citedOpen Access
PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients’ RBCs ex vivo in the frame of Protein Replacement Therapy
Journal of Biological Research - Thessaloniki·2021· 7 citedOpen Access
In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations
Molecular Genetics and Metabolism Reports·2020· 13 citedOpen Access
CCDC 1994154: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Effect of the triphenylphosphonium cation on the biological properties of new rhenium and technetium-99m fac-[M(CO)3(NSN)]±-type complexes: Synthesis, structural characterization, in vitro and in vivo studies
Inorganica Chimica Acta·2020· 3 cited
Correction to: In Vitro-Transcribed (IVT)-mRNA CAR Therapy Development
Methods in molecular biology·2020· 3 cited
In Vitro-Transcribed (IVT)-mRNA CAR Therapy Development
Methods in molecular biology·2019· 31 cited
Organometallic rhenium tricarbonyl–enrofloxacin and –levofloxacin complexes: synthesis, albumin-binding, DNA-interaction and cell viability studies
JBIC Journal of Biological Inorganic Chemistry·2019· 29 cited
Tackling pharmacological response heterogeneity by PBPK modeling to advance precision medicine productivity of nanotechnology and genomics therapeutics
Expert Review of Precision Medicine and Drug Development·2019· 24 cited
Production and Transduction of a Human Recombinant β-Globin Chain into Proerythroid K-562 Cells To Replace Missing Endogenous β-Globin
Molecular Pharmaceutics·2018· 9 cited
CAR T-cell Therapy: A New Era in Cancer Immunotherapy
Current Pharmaceutical Biotechnology·2018· 462 cited
CCDC 1427952: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
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Frequent Co-authors

Asterios S. Tsiftsoglou(17), Αndroulla N. Miliotou(16), Dionysia Papagiannopoulou(8), Ioannis S. Pappas(8), Ioannis S. Vizirianakis(6), Antonios G. Hatzidimitriou(4), Efthymia Vlachaki(4), Parthena Foltopoulou(4), Sofia K. Georgiou‐Siafis(4), Carolyn M. Sue(3), Kurenai Tanji(3), Rudy Van Coster(3), Paige Kaplan(3), Sara Shanske(3), Darryl C. De Vivo(3), Michio Hirano(3), Francesco Pallotti(3), Evangelos Tsoukas(3), George Psomas(3), Georgios C. Kaiafas(3)