Guillermo Güenechea

Centre for Biomedical Network Research on Rare Diseases — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.7kcitations68works0.02yr avg
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Research Topics

CRISPR and Genetic Engineering(30), Virus-based gene therapy research(29), RNA Interference and Gene Delivery(20), Hematopoietic Stem Cell Transplantation(13), Pluripotent Stem Cells Research(13)

Publications67 total

Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths
Scientific Reports·2025Open Access
The gray boundaries of aberrant shortening of the cellular timekeepers’ edges
EMBO Molecular Medicine·2024Open Access
GSE4‐loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage
The FASEB Journal·2021· 10 citedOpen Access
Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1
Stem Cell Research & Therapy·2021· 2 citedOpen Access
Generation of Dyskeratosis Congenita-like Hematopoietic Stem Cells through the Stable Inhibition of DKC1
2021Open Access
Generation of Dyskeratosis Congenita-like Hematopoietic Stem Cells through the Stable Inhibition of DKC1
2020Open Access
Generation of Dyskeratosis Congenita-like Hematopoietic Stem Cells through the Stable Inhibition of DKC1
2020Open Access
Significant impact of mesenchymal stromal cell co-transplantation in a challenging hematopoietic engraftment scenario comparing two administration routes
Cytotherapy·2020
Targeted gene therapy into a safe harbor site in human hematopoietic progenitor cells
Gene Therapy·2020· 5 citedOpen Access
Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia
Nature Medicine·2019· 171 cited
Advances in the gene therapy of monogenic blood cell diseases
Clinical Genetics·2019· 26 cited
Author response for "Advances in the Gene Therapy of Monogenic Blood Cell Diseases"
2019
Author response for "Advances in the Gene Therapy of Monogenic Blood Cell Diseases"
2019
GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells
Cell Death and Differentiation·2019· 28 citedOpen Access
Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency
Scientific Reports·2018· 8 citedOpen Access
Generation and potential applications of an X-linked dyskeratosis congenita model in human hematopoietic stem cells.
IBJ Plus·2018
Generation and potential applications of an X-linked dyskeratosis congenita model in human hematopoietic stem cells.
IBJ Plus·2018Open Access
Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors
Molecular Therapy·2018· 70 citedOpen Access
Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34+ cells from Fanconi anemia patients
Blood·2017· 57 cited
Mutations in XLF/NHEJ1/Cernunnos gene results in downregulation of telomerase genes expression and telomere shortening
Human Molecular Genetics·2017· 19 citedOpen Access
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Frequent Co-authors

Juan A. Bueren(41), José C. Segovia(25), Susana Navarro(13), Paula Rı́o(12), M. Luz Lozano(12), Elena Almarza(8), María L. Lamana(7), África González‐Murillo(6), Julián Sevilla(5), Manuel Ramı́rez(5), Óscar Quintana-Bustamante(5), Laura Pintado‐Berninches(5), Cristina Manguán-García(5), Leandro Sastre(5), Rosario Perona(5), Francisco J. Molina-Estévez(5), Jordi Surrallés(4), Olga I. Gan(4), Craig Dorrell(4), John E. Dick(4)